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Apoptosis of Substantia Nigra Dopaminergic Neurons in C57BL Mice Exposed to Paraquat for Different Periods

DING Zheng-Tong, REN Hui-Min, JIANG Yu-Ping Department of Neurology, Huashan Hospital, Fudan University, Shanghai 200040,China  
Aim: To investigate the death mode of substantia nigra dopaminergic neurons in C57BL mice exposed to paraquat. Methods: TdT-mediated biotinylated-dUTP nick end labeling (TUNEL)method and tyrosine hydroxylase (TH) immunohistochemistry, flow cytometry and electronic microscopy were performed to detect apoptosis of substantia nigra dopaminergic neurons in mice exposed orally to paraquat for different periods. Results :TH immunohistochemistry and TUNEL method showed apotoric neurons in substantia nigra after C57BL mice exposed to paraquat by orally administration for 2 weeks, apoptotic neurons were most when mice exposed for 1 month, compared with the control, P 0.001; and were decreased when mice exposed to paraquat for 2 months, but still more than the control, P 0.01.Conclusion: Paraquat could induce apoptosis of substantia nigra dopaminergic neurons when C57BL mice exposed to paraquat for a relative long period.
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