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The Influence of Paraquat on Cerebral Mitochondrial Respiratory Chain Activity After Mice Exposed to Paraquat by Oral Administration

DING Zheng-Tong, JIANG Yu-Ping ▲,REN Hui-Min,LU Yuan  Department of Neurology, Department of Laboratory Medicine Huashan Hospital, Fudan University, Shanghai 200040,China  
Aim:To explore the influence of paraquat on cerebral mitochondrial respiratory chain activity and the possible mechanism of paraquat to damage nigral neurons.Methods:Activities of complex Ⅰ,complex Ⅱ, complex Ⅳ and citrate synthase were measured after mice exposed to paraquat or MPTP or the same amount normal saline administered orally every day for 2 months. Results:The results showed that complex Ⅰ activities significantly decreased in substantia nigra and striatum but unchanged in fraontal lobe or cerebellum when mice subchronically exposed to paraquat or MPTP, and no differences of the activities of complexⅡ,complex Ⅳ and citrate synthase were found among paraquat-treated group, MPTP-treated group and control group. Conclusion:These results suggest that paraquat after cross the blood-brain barrier might induce mitochondrial dysfunction in substantia nigra and striatum.
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