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《Chinese Journal of Clinical Neurosciences》 2004-02
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The Impairing Compare of PQ and ES to the Dopaminergic System and the Acetylnergic System in the Brain of C57BL Mice

YANG Xing-Ling , JIANG Yu-Ping,WENG Jian-Ying ,DING Zheng-Tong.Department of Neurology,Huashan Hospital, Fudan University, Shanghai 200040,China Department of Neurology,First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054,China  
Aim:To study the impairing compare of PQ and ES to the dopaminergic system and the acetylnergic system in the brain of C57BL mice. Methods:C57BL mice well administered orally with PA, MPTP, ES. Sponteneous behavior was monitored. The levels of AChR in the cortex, striatum, hippocampus and thalamus, the DAT and DAD 2R in the striatum were detected by autoradiography.Results:Comparing to the control group, there was no significant change in mAChR in the brain of PQ, ES and MPTP treated mice. However, DAT and DAD 2R were significantly decreased in the striatum.Conclusion:PQ and ES mainly damage the dopaminergic system, but has little effect on the acetylnergic system in the brain of mice.
【Fund】: 上海市科委自然科学基金资助 (0 0 4 1 1 90 0 5)
【CateGory Index】: R742.5
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【References】
Chinese Journal Full-text Database 1 Hits
1 WU Jian-Jun, REN Hui-Min, JING Yu-Ping* Department of Neurology, Huashan Hospital, Fudan University, Shanghai 200040, China;Analysis of GSTP1 mRNA Expression in the Mice with Paraquat Treatment[J];Chinese Journal of Clinical Neurosciences;2006-02
【Citations】
Chinese Journal Full-text Database 3 Hits
1 REN Jin Peng,REN Hui Min,JIANG Yu Ping Department of Neurology,Huashan Hospital, Fudan University, Shanghai 200040,China;Decrease of Dopamine Transporter in Striatum of Parkinsonian Mice Induced by Paraquat[J];Chinese Journal of Clinical Neurosciences;2002-01
2 DING Zheng Tong, REN Hui Min,JIANG Yu Ping , et al. Department of Neurology, Huashan Hospital, Fudan University, Shanghai 200040,China;Adult C57b1 Mice Could Develop Symptoms Similar to Parkinson′s Disease after the Exposure to Paraquat[J];Chinese Journal of Clinical Neurosciences;2002-03
3 FANG Ping, WU Chunying, CHEN Zhengping, et al State Key Laboratory of Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, Wuxi 214063;Preparation and animal studies of 99 TcmTRODAT1 as a dopamine transporter imaging agent[J];CHINESE JOURNAL OF NUCLEAR MDEICINE;1999-03
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 ;Brain Receptor Imaging[J];China Comtemporary Medicine;2001-09
2 ;The Imaging of Dopamine Transporter in Brain--αNew Method for Diagnosis of Parkinson's Disease[J];China Comtemporary Medicine;2001-12
3 JIANG Zhong WANG Feng LIU Zengli TANG Jun WU Jinchang (Department of Nuclear Medicine, Second Hospital Affiliated to Suzhou University, Nuclear Medicine Institute of Suzhou University, Suzhou 215004);Calculation of the internal radiation absorbed dose of ~(99m)Tc-TRODAT-1[J];Nuclear Techniques;2002-11
4 ZHAO Yong Fei, JIANG Yu Ping, CHEN Zhen Ping , et al Department of Neurology,Huashan Hospital, Fudan University, 200040; State Key Laboratory of Nuclear Medicine, Jiangsu Institute of Nuclear Medicine, 214063,China;Evaluation of the Value for ~(99m)Tc-TRODAT-1 SPECT Imaging of Dopamine Transporter in Diagnosis of Parkinson's Disease[J];Chinese Journal of Clinical Neurosciences;2002-03
5 DING Zheng-Tong, REN Hui-Min, JIANG Yu-Ping Department of Neurology, Huashan Hospital, Fudan University, Shanghai 200040,China;Apoptosis of Substantia Nigra Dopaminergic Neurons in C57BL Mice Exposed to Paraquat for Different Periods[J];Chinese Journal of Clinical Neurosciences;2003-01
6 DING Zheng-Tong, JIANG Yu-Ping ▲,REN Hui-Min,LU Yuan  Department of Neurology, Department of Laboratory Medicine Huashan Hospital, Fudan University, Shanghai 200040,China;The Influence of Paraquat on Cerebral Mitochondrial Respiratory Chain Activity After Mice Exposed to Paraquat by Oral Administration[J];Chinese Journal of Clinical Neurosciences;2003-03
7 YANG Li-Qin, JIANG Yu-Ping, WANG Jian, ZHANG Zhen-Xin, XIE Hui-Jun, XIANG Jing-De, LIU Xing-Dang, DING Zheng-Tong, WU Jian-Jun, SU Hui-Ling, CHEN Zheng-Ping, GUO Li-Ping, LIU Nan Department of Neurology, Shanghai Medical College, Fudan University, Shanghai 200032; Department of Neurology and Department of Nuclear Medicine, Huashan Hospital, Fudan University, Shanghai 200040, China;The Influence of Different Antiparkinsonian Drugs on Dopaminergic System in Basal Ganglion[J];Chinese Journal of Clinical Neurosciences;2005-02
8 LI Jian,FAN Yi-Jun ,CHEN Kan,LI Ling,BAO Jian-Dong.Department of Neurology,Affiliated Jiangyuan Hospital,Jiangsu Institute of Nuclear Medicine,Wuxi 214063,China;~(99)Tc~m-TRODAT-1 DAT SPECT Imaging on Human Brain in the Early Diagnosis of Parkinson's Disease[J];Chinese Journal of Clinical Neurosciences;2005-03
9 GUO Yanping, WANG Feng , SHI Jingping, DI Qing ZHANG Yindong Department of Neurology, the Nanjing Brain Hospital and Nuclear Medicine Department, NO. 1 Hospital Affiliated to Nanjing Medical University. Nanjing 210006, China;Prelimminary clinical application of dopamine transporter imaging with technetium-99m TRODAT-1 and SPECT in Parkinsons disease[J];Journal of Brain and Nervous Diseases;2005-01
10 ZHOU Pei-qing(College of Clinical Medicine,Inner Mongolia University for Nationalities,Tongliao 028041,China);The Application of Nuclear MedicineImaging Technique in Parkinson's Disease[J];Journal of Inner Mongolia University for Nationalities(Natural Sciences,Quarterly);2005-03
【Co-references】
Chinese Journal Full-text Database 3 Hits
1 DING Zheng-Tong, REN Hui-Min, JIANG Yu-Ping Department of Neurology, Huashan Hospital, Fudan University, Shanghai 200040,China;Apoptosis of Substantia Nigra Dopaminergic Neurons in C57BL Mice Exposed to Paraquat for Different Periods[J];Chinese Journal of Clinical Neurosciences;2003-01
2 ZHANG Ke-Zhong, JIANG Yu-Ping, WANG Jian,et al Department of Neurology, People' s Hospital of Jiangsu Province, Nanjing 210029; Department of Neurology, Huashan Hospital, Fudan University, Shanghai 200040, China;Synergistic Toxic Effect of Paraquat and Lactacystin on Substantia Nigra[J];Chinese Journal of Clinical Neurosciences;2005-01
3 REN Jin-Peng 1,2 , REN Hui-Min 1* , JIANG Yu-Ping 1* . 1. Department of Neurology, Fudan University Affiliated Huashan Hospital, Shanghai 200040, 2.Department of Neurology, Shanghai Jiaotong University Affiliated Sixth People's Hospital,Shanghai 200232,China;Selective Damage of Paraquat on Dopaminergic Neurons in Substanti Nigra of Mice[J];Chinese Journal of Clinical Neurosciences;2005-03
【Secondary Citations】
Chinese Journal Full-text Database 2 Hits
1 WANG Jian,CAI Zhen lin,REN Hui min,LU Chuan zhen,JIANG Yu ping (Department of Neurology,Huashan Hospital,Shanghai Medical University,Shanghai 200040);Damage of Paraquat and Dieldrin on Cultured Rat Dopaminergic Neurons[J];JOURNAL OF SHANGHAI MEDICA(UNIVERSITY);2000-04
2 DING Zheng tong,REN Hui min,JIANG Yu ping,CAI Zhen ling △ ,ZHU Qiu yu △△ (Department of Neurology, △△ Department of Diabetes Research,Huashan Hospital,Fudan University, Shanghai 200040; △Department of Medicine,Minhang H;Influence of Paraquat on the System of Substantial Nigra and Striatum in C57BL Mice[J];Journal of Shanghai Medica(University);2001-01
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