The Impairing Compare of PQ and ES to the Dopaminergic System and the Acetylnergic System in the Brain of C57BL Mice
YANG Xing-Ling , JIANG Yu-Ping,WENG Jian-Ying ,DING Zheng-Tong.Department of Neurology,Huashan Hospital, Fudan University, Shanghai 200040,China Department of Neurology,First Affiliated Hospital, Xinjiang Medical University, Urumqi 830054,China
Aim:To study the impairing compare of PQ and ES to the dopaminergic system and the acetylnergic system in the brain of C57BL mice. Methods:C57BL mice well administered orally with PA, MPTP, ES. Sponteneous behavior was monitored. The levels of AChR in the cortex, striatum, hippocampus and thalamus, the DAT and DAD 2R in the striatum were detected by autoradiography.Results:Comparing to the control group, there was no significant change in mAChR in the brain of PQ, ES and MPTP treated mice. However, DAT and DAD 2R were significantly decreased in the striatum.Conclusion:PQ and ES mainly damage the dopaminergic system, but has little effect on the acetylnergic system in the brain of mice.