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《Journal of Clinical Neurosurgery》 2015-04
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Observation of effect and analysis of safety of Bevacizumab combined with chemotherapy for patients with recurrent malignant gliomas

XIANG Wei;CHEN Dong;HU Ji-liang;Department of Neurosurgery,Shenzhen People’s Hospital;  
Objective To explore the efficiency and safety of bevacizumab combined with chemotherapy for patients with recurrent high-grade gliomas. Method According to selected standard,11 recurrent high grade glioma patients accepted bevacizumab combined with temozolomide( TMZ) from March 2011 to December 2013 were analyzed retrospectively. The effect of chemotherapy was evaluated according to tumor MRI enhanced image range and KPS and QOL score between treatment and recurrent progression. Side effects were determined according to WHO anti-cancer drugs acute and subacute toxic reaction criterion. Result All of the 11 cases were accepted more than 2circle chemotherapy,there were 4 cases with complete response( CR),6 cases with partial response( PR),1 case with stable disease( SD) and 0 case with progressive disease( PD). And the objective response rate( RR) was 90. 9%,and disease control rate was 100%. The PFS was 5. 4 months and OS was 6. 5 months. The most commonly adverse events of bevacizumab combinded with TMZ were gastrointestinal adverse reactions( 66. 3%),bone marrow suppression( 43. 2%), kidney injury( 39%),hypertension( 27. 3),and most were grade Ⅰ-Ⅱ( 35. 93%) and grade Ⅲ were rare( 2. 6%),no grade Ⅳ. The KPS and QOL score were improved significantly after treatment compared to them before treatment( all P 0. 05). Conclusion Bevacizumab combined with TMZ treatment shown an effective anti-high grade gliom and good control rate and safety. It is a prior alternative treatment method for recurrent high-grade gliomas.
【Fund】: 深圳市科创委项目(201203120)
【CateGory Index】: R739.4
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