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《Practical Clinical Medicine》 2004-03
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Effects of Quercetin on P-selectin of Rats with Acute Lung injury Induced by lipopolysaccharide

Ji Xian-fei 1, Liu Wei 2, Huang Liang 1 (1.Department of Emergency Medicine,the First Affiliated Hospital of Jiangxi Medical College,Nanchang 330006,China; 2.Department of Pharmacy,the Infections Disease Hospital of Jining,Jining 272027,China)  
Objective: To investigate the effects of quercetin on P-selectin of rats with lipopolysaccharide-induced acute lung injury(ALI).Methods:lipopolysaccharide(LPS,6 mg/kg,iv)reproduced the model of ALI in 24 SD rats were randomly divided into three group:control group、LPS group、Quercetin pretreatment group.At six hours after lipopolysaccharide or normal saline was given, the rats of each group were killed and the pathological manifestation of the lung was observed. The wet and drought ratio(W/D)and PaO 2 were calculated,and the levels of P-selectin in serum(or plasma) and lung tissue were also measured by the mothod of radioimmunoassay.Results:At six hours after LPS administering intravenously, the levels of W/D、PaO 2P-selectin were increased significantly(P0.01).These changes were markedly attentuated in Quercetin pretreatment group(P0.01 or P0.05)and the pathological manifestation of lung was also meliorated.Conclusion:Quercetin has a protective effect on LPS-induced acute lung injury in rats through inhibiting the P-selectin mediator and improving gas exchange ability.
【CateGory Index】: R965
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【References】
Chinese Journal Full-text Database 1 Hits
1 XIAO Xiao-hui,FU Ming-sheng,WAN Yi-xin.Department of Respiratory Disease,Second Hospital,Lanzhou University.Lanzhou,Gansu,730030,China;Therapeutic effects of quercetin against paraquat-induced acute lung injury in rats[J];Chinese Journal of Respiratory and Critical Care Medicine;2007-04
【Citations】
Chinese Journal Full-text Database 1 Hits
1 WANG ChangMing, HUANG Hui, ZHANG ZhenXiang,MO BiWen, BAI Jing,ZENG JinRong, JIANG ShuKe, REN Ge, WANG JiYing (Dept of Respiratory Disease, Affiliated Hospital of Guilin Medical College, Guilin 541001);The protective effects of quercetin on Bleomycin-Induced pulmonary fibrosis in rats[J];CHINESE PHARMACOLOGICAL BULLETIN;2000-01
【Co-citations】
Chinese Journal Full-text Database 9 Hits
1 HUANG Liang,JI Xianfei,CAO Chunshui,et al.Department of Emergency medicine,the First Affiliated Hospital of Jiangxi Medical College,Nanchang 330006,China;Protective effects of quercetin in rats with lipopolysaccharide-induced acute lung injury[J];Journal of Emergency Medicine;2004-02
2 ZHANG Xiaoxuan,NA Yu,MIAO Lining,et alDepartment of Nephrology,the Fourth Hospital, Jilin University,Changchun (130011);Effects of Quercetin on Renal Interstitial Fibrosis and Expression of α-SMA in UUO Rats[J];Chinese Journal of Integrated Traditional and Western Nephrology;2006-10
3 WANG Xiang-ying,WU Shu-yan,LI Su-an,et al (Department of Electron Microscope, Medical School of Suzhou University, Jiangsu Suzhou 215007, China);Study on Pathomorphology and Ultrastructure of Rat Pulmonary Fibrosis Model[J];Acta Academiae Medicinae Suzhou;2005-03
4 SUN Zengtao, LIAN Fu, LI Yuechuan, XU MeilinThe Second Hospital of Tianjin Chinese Medical University,Tianjin 300051,China;The Effection of QiZhuHeJi Treating Rats with Pulmonary Fibrosis on TGF-β_1[J];Tianjin Medical Journal;2006-04
5 Zhang Xiao-xuan1, Zhang Xiao-dong1, Yuan Hong-ping1, Na Yu1, Miao Li-ning2, Hu Xiu-li1, Zheng Wei1, Li Gen1 1Department of Nephrology, Fourth Hospital of Jilin University, Changchun 130011, Jilin Province, China; 2Department of Nephrology, Second Hospital of Jilin University, Changchun 130041, Jilin Province, China;Regulative effects of quercetin on transforming growth factor beta 1 and connective tissue growth factor in kidney tissue in rats with unilateral ureteral occlusion[J];Chinese Journal of Clinical Rehabilitation;2006-31
6 CHAI Wen Shu, LI Yong Chun, WANG Hong Xin 1, GUO Min 1,LI Yan Qin 1 (Dept of Respiratory Medicine,The First Affiliated Hospital, 1Jinzhou Medical College,Jinzhou 121001);The effects of angelica sinensis on pulmonary fibrosis in rats[J];Chinese Pharmacological Bulletin;2003-07
7 YANG Xiu-ying,DU Guan-hua (Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050,China);Micro volume assay method of hydroxyproline in animal tissues and application[J];Chinese Pharmacological Bulletin;2004-07
8 LIAN Li-yan1,2,FENG Yi-zhong2,GU Zhen-lun1,3,JIANG Xiao-gang1,4,ZHOU Wen-xuan1,GUO Ci-yi1 (1.Suzhou Institute of Chinese Materia Medica,Suzhou Jiangsu 215007,China;2.Dept of Pathology and Pathophysiology,Soochow University School of Medicine,3.Laboratory of Senile and Nerval Disease,Soochow University,4.Dept of Pharmacology,Soochow University School of Medicine,Suzhou Jiangsu 215123,China);Effects of epigallocatechin gallate on rats with pulmonary fibrosis induced by bleomycin[J];Chinese Pharmacological Bulletin;2009-05
9 Yang Jun,Pan Qiang,Wang Shiling,Wu Kun(Department of Pharmacy,Hospital Affiliated to the Academy o f Military Sciences,Beijing,China 100039);The Advance on Treatment Pulmonary F ibrosis by Chinese Herbs[J];China Pharmaceuticals;2004-08
【Co-references】
Chinese Journal Full-text Database 3 Hits
1 HUANG Liang,JI Xianfei,CAO Chunshui,et al.Department of Emergency medicine,the First Affiliated Hospital of Jiangxi Medical College,Nanchang 330006,China;Protective effects of quercetin in rats with lipopolysaccharide-induced acute lung injury[J];Journal of Emergency Medicine;2004-02
2 CAO Yu~*,DONG Yulong,YAO Yao,et al.~*Department of Emergency Medicine,West China Hospital,Sichuan University.Chengdu,Sichuan 610041,China;A study on the pathogenesis of acute paraquat intoxication induced pulmonary injury[J];Chinese Journal of Respiratory and Critical Care Medicine;2005-04
3 Xie Meilin,Gu Zhenlun and Qian Zengnian (Dept Pharmacology,Suzhou Medical College,Suzhou 215007);Study on the anti-active oxygen effects of quercetin[J];CHINESE WILD PLANT RESOURCES;1997-02
【Secondary Citations】
Chinese Journal Full-text Database 1 Hits
1 LI Qi, QIAN Guisheng, CHEN Zhengtang,et al Institute of Respiratory Diseases, Xingqiao Hospital, Third Military Medical University, Chongqing, 400037;A preliminary study on the markers of pulmonary vascular endothelial cells in patients with ARDS[J];CHINESE JOURNAL OF TUBERCULOSIS AND RESPIRATORY DISEASES;1999-09
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