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《Clinical Misdiagnosis & Mistherapy》 2006-06
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Antineoplastic and Anti-metastasizing Effects of Runing Ⅱ on Breas Cancer in Mice:An Experimental study

JIA Xi-hua,TANG Han-jun~*,ZHAO Lian-chen,GENG Shu-mei(The First Central Hospital of Baoding City,Baoding,Hebei 071000,China)  
Objective:To investigate antineoplastic and antimetastasizing effects of Runing Ⅱprescription on Jinbai II(TA2)mouse breast cancer line MA891.Methods:In vitro culture MA891 cells were inoculated subcutanously into Jinbai II mice(TA2).And then tne mice were divided into four groups and treated respectively with normal saline,cyclophosphamide(CTX),Runing Ⅱ and cyclophosphamide(CTX) plus Runing Ⅱ.The growth of tumors and lung metastasis were observed and compared among the four groups.Results:Tumor inhibition rates were 72.14%、35.1%、73.90% in CTX group、Runing Ⅱ group and CTX+Runing Ⅱgroup,respectively;the inhibition rates of lung metastases were 38.03%,34.04%,56.91%,respectively.Conclusion:Runing Ⅱprescription could inhibit the growth of the tumor and reduce the lung metastases.And it could also reduce the toxicity of CTX abd enhance its therapeutic effectiveness.
【CateGory Index】: R737.9
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