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《Clinical Misdiagnosis & Mistherapy》 2010-10
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Risk Factor Analysis of Superinfection Following Carbapenems Therapy in Patients with Severe Lower Respiratory Tract Infection

ZHANG Li-juan,SHI Jin-ying,LIANG Gui-qin,YANG Ai-cong(Department of Respiratory,Center Hospital of Shijiazhuang,Shijiazhuang 050000,China)  
Objective To discuss the high risk factors of superinfection after carbapenems in treatment of patients with severe lower respiratory tract infection,and provide reference for prediction and reduction of superinfection.Methods The clinical data of severe lower respiratory tract infection patients treated by carbapenems for more than 5 d were selected,and the risk factors associated with the superinfection were analyzed.Results 53 patients were enrolled in the group.Pathogenetic conditions in 43 patients(81.1%)significantly improved after carbapenems treatment,and 38 patients had risk factors of superinfection,among whom 11 patients had superinfection with a 28.9% superinfection rate.In Pearson correlation analysis,the 5 factors closely related with superinfection were age(r=0.412,P=0.010),mechanical ventilation(r=0.673,P=0.000),hypoproteinemia(r=-0.769,P=0.000),carbapenems treatment time(r=0.843,P=0.000),acute physiology and chronic health evaluation Ⅱ(APACHE Ⅱ)Score of critical patients(r=0.815,P=0.000).Conclusion Mechanical ventilation,hypoproteinemia,carbapenems treatment time and APACHE Ⅱ score are high risk factors of superinfection after carbapenems treatment in patients with severe lower respiratory tract infection.
【CateGory Index】: R563.1
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