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《Clinical Misdiagnosis & Mistherapy》 2011-03
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Clinical Effect and Mechanism of Butylphthalide Soft Capsules in Treatment of Vascular Dementia

LU Hai-li,YANG Jian-fang,LIANG Gui-qin,ZHU Rong-yan,HOU Yong-ge,ZHANG Jing-rui,XU Yue-kun(the Second Department of Neurology,the Central Hospital of Shijiazhuang City,Shijiazhuang 050011,China)  
Objective To observe the effect and safety of Butylphthalide Soft Capsules in treatment of vascular dementia(VD),and to research the probable mechanisms.Methods100 mild and moderate VD patients were randomly divided into Butylphthalide group and Nimodipine group.Both groups were treated for 3 months.Efficacy was assessed by MMSE,ADL and CDR scale 1 day before treatment and in the 2nd,4th and 12th weeks after treatment.The improvement of symptom and safety of drug use were evaluated before and after treatment.ResultsThere was significant difference of scale in both groups before and 12 weeks after treatment(P0.05),and there was significant difference between the two groups(P0.05);the total effect rate in Butylphthalide group was 84.9%,while 64.0% in Nimodipine group,There was significant difference between the two groups(P0.05),but the incidences of adverse events in the two groups showed no significant difference(P0.05).ConclusionButylphthalide Soft Capsules is more effective in treating mild and moderate VD than Nimodipine,and is safe to clinical application.
【CateGory Index】: R749.13
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【Citations】
Chinese Journal Full-text Database 6 Hits
1 Sun Yuhua1),Lu Hong2),He Wei-ya1).1)Department of Neurology,the Affiliated Huaihe Hospital of Henan University,Kaifeng 475000 2)Department of Neurology,the First Affiliated Hospital of Zhengzhou University,Zhengzhou 450052,China;Effects of Dingbentai on the expression of nNOS and SS in vascular dementia rats[J];Chinese Journal of Practical Nervous Diseases;2008-11
2 CHEN Songchun,HONG Zhen,WEI Wenshi.Department of Neurology,Hua Dong Hospital,Shanghai 200040,China;Comparative Study in the Treatment of Acute Ischemic Cerebrovascular Diseases with dl-3-butylphthalide[J];Applied Journal of General Practice;2006-06
3 WT4”,5BZ]XIONG Jie, FENG Yi Pu (Institute of Materia Medica, Chinese Academy of Medical Science, Peking Union Medical College, Beijing 100050, China) [WT4”,5HZ];THE PROTECTIVE EFFECT OF BUTYLPHTHALIDE AGAINST MITOCHONDRIAL INJURY DURING CEREBRAL ISCHEMIA[J];ACTA PHARMACEUTICA SINICA;2000-06
4 HUANG Ru-xun,LI Chang-xin,CHEN Li-yun,XIE Long-chang,WEN Hong-mei,LIAO Song-jie,SHI Xiao-geng,YE Qing-yong,LIN Jian-wen,WANG Xin,LIU Chun-ling(The First Hospital Affiliated to Sun Yat-Sen University, Guangzhou 510080 China);Effects of dl-3n-butyphthalide in the treatment of rat cerebral infarction with middle cerebral artery occlusion[J];Chinese New Drugs Journal;2005-08
5 WANG Bing~1 WANG Pei~2 KANG Jun~1 L(?) Pei-yuan~3 (1 Department of Neurology,The Third Hospital of Hebei Medical University,Shijiazhuang 050051,China; 2 Department of Neurology,The Second Hospital of Hebei Medical University,Shijiazhuang 050000,China; 3 Hebei Provincial People's Hospital,Shijiazhuang 050051,China);Effect of dl-3n-butyphthalide on learning,memory and hippocampal NR2B expression in mice with vascular dementia[J];Chinese Journal of New Drugs;2008-01
6 Dong Gao-xiang, Feng Yi -Pu (Department of Pharmacology,Institute of Materia Medica,CAMS and PUMC,Beijing100050,China);Effects of NBP on ATPase and Anti-oxidant Enzymes Activities and Lipid Peroxidation in Transient Focal Cerebral Ischemic Rats[J];Acta Academiae Medicinae Sinicae;2002-01
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 YU Huawei, XIE Xiaoping, LIU Fengting, et al\ Department of Clinical Laboratory, No. 401 Hospital of PLA, Qingdao 266071;INFLUENCE OF HYPERBARIC OXYGEN ON CELL APOPTOSIS OF Ara c INDUCED ACUTE MYELOID LEUKEMIA: AN IN VITRO STUDY[J];Acta Acadimae Medicinae Qingdao;2002-04
2 YU Wen gang, SUN Xiao yan (Department of Anesthetics, The Affiliated Hospital of Qingdao University Medical College, Qingdao 266003, China);EFFECT OF AMRINONE ON HEMODYNAMICS DURING OPERATION FOR RECTAL CARCINOMA IN ELDERLY PATIENTS ASSOCIATED WITH HYPERTENSION[J];Acta Acadimae Qingdao Umvesitatis;2004-03
3 HAN Mingji, ZHAO Xinxin Huichun Hospital, Huichun 133300, China;Application of Nicardipine hydrochlorid to prevention and treatment of cerebrovascular spasm after subarachnoid hemorrhage[J];Chinese Journal of Neuromedicine;2003-01
4 HE Xiao-rong1,ZHAO Li-bo2(1.Research Department;2.Neurol Department,The Third People′s Hospital of Chongqing,Chongqing 400014,China);Therapeutic effects of Dl-3n-butyphthalide combined batroxobin on treating acute ischemic stroke[J];Chongqing Medicine;2009-12
5 ;Progress in Development and Application of Antiplatelet Agents[J];;1999-07
6 LU Zi Min 1, ZHANG Qi Xi 2, XIU Bing 1, WU Jin Ying 1, ZHENG Wei Ping 1 (1. Department of Hematology,Tongji Hospital,Tongji University, Shanghai 200065,China; 2. Department of Internal Medicine,Shanghai Liqun Hospital, Shanghai 200333);Correlation between expression of platelet membrane glycoproteins and hyperviscosity syndrome[J];Academic Journal of Second Military Medical University;2004-04
7 Zhou Zhongjiang 1, Ye Haiyan 2, Wu Saizhu 1, Meng Surong 1 1 Department of Cardiac Diseases, Nanfang Hospital, First Military Medical University, Guangzhou, 510515; 2 Department of Obstetrics, Sun Yat-sen Memorial Hospital, Sun Yat-Sen Ui;Effect of nitric oxide precursor-L-arginine-related peptide on rat platelet aggregation, thrombsis and the plasma levels of nitric oxide, cyclic guanine monophosphate and prostacyclin[J];JOURNAL OF FIRST MILITARY MEDICAL UNIVERSITY;1999-06
8 HOU De-ren1, WAN Shun1, ZHOU Jun2, CHEN Kun1, TIAN Yi1 1Department of Neurology, 2Center of Medical Experiment, Third Xiangya Hospital, Central South University, Changsha 410013, China;Effect of butylphthalide on the expression of S100 and glial fibrillary acidic protein in a rat model of Alzheimer disease[J];Journal of Southern Medical University;2009-06
9 XU Li\+1,LI Xiang-Lu\+1,HUANG Yi-Bing\+1,WU Xiao-Xia\+1,HOU Rui-Zhen\+1, WANG Hua\+2,WANG Na\+1,ZHANG Xue-Zhong\+\{1*\} [WT5”BX](1. Key Laboratory for Molecular Enzymology and Engineering of the Ministry of Education,Jilin University,Changchun 130023;2. China-Japan Union Hospital of Jilin University,Changchun 130031,China) [WT5HZ];Protection of Small Molecule Corn Peptide Leu-Asp-Tyr-Glu from Mitochondria Against Oxidative Damage[J];Chemical Research In Chinese Universities;2004-06
10 Wang Xuetao,Li Guanhe (Department of Medicine,Hospital of Nanhai West Oil Corporation,Zhanjiang, 524057);Dynamic blood pressure monitoring of the antihypertensive efficacy of indapamide[J];JOURNAL OF GUANGDONG MEDICAL COLLEGE;1998-04
China Proceedings of conference Full-text Database 2 Hits
1 LIU Xingkui WU Huahui YU Jianghong TCM Hospital of Haerbin City,Heilongjiang,Haerbin 150076,China;Clinical observation on Shensongyangxin capsule in treatment of ventricular premature contraction[A];[C];2007
2 Xiong Jie~1 Xu Pingxiang~1 Sun lina~1 Cheng Liang~1 Feng Yipu~2 Wang Xiaoliang~2 (~1 Department of Pharmacology,School of Chemical Biology and Pharmacal Science,Capital Medical University,Beijing 100069;~2 Institute of Materia Medica,Chinese Acedimy of Medical Sciences·Peking Union Medical Colloge,Beijing 100050);The protective effects of butylphthalide on mitochondria against hypoxia/hypoglycaemia in cultured neurons[A];[C];2007
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 CUI Li-ying *, LI Shun-wei, LU Chuan-zhen,DONG Qiang,DONG Peng,SHI Lang-feng,HUANG Jian-zheng,MAO Shan-ying,ZHANG Chao-dong,CAO Yun-peng,NIE Ying-xue,WANG Wei-zhi, LIANG Qing-cheng,YANG Xiao-chun,DONG Wei-wei,LI Guang-qin,PENG Guo-guang,LUO Zu-ming,HE Li,WAN Qi,HAN Jun-liang,HUANG Ru-xun,LI Ling,LI Cheng-yan,MENG Zhen-zhong. *Department of Neurology, Peking Union Medical College Hospital, Chinese Academy of Medical Science, Beijing 100730, China;The multicentric randomized study of dl-3-butylphthalide in the treatment of acute moderate ischemic stroke[J];Chinese Journal of Cenebrovascular Diseases;2005-03
2 Bei Zhang~1, Hai-Qin Wu~1, Hai-Xiong Zhang~2 ~1Department of Neurology, the Second Hospital of Xi'an Jiaotong University, xi'an 710004, China; ~2Department of Otorhinolaryngology, the Affiliated Hospital of Shaanxi Medical College, Xi'an 710077, China;Neurobiochemical Mechanisms of Vascular Dementia[J];Cerebrovascular Diseases Foreign Medical Sciences;2005-09
3 DONG JIAN-WEN; SHI AN-YUN(Department of Pathophysiology, Beijing Medical University, Beijing 100083);PROTECTION OF SUPEROXIDE DISMUTASE ON HYPOXIA-REOXYGENATION INJURY TO ENDOTHELIAL CELL[J];ACTA PHYSIOLOGICA SINICA;1997-06
4 CHEN Songchun,HONG Zhen,WEI Wenshi.Department of Neurology,Hua Dong Hospital,Shanghai 200040,China;Comparative Study in the Treatment of Acute Ischemic Cerebrovascular Diseases with dl-3-butylphthalide[J];Applied Journal of General Practice;2006-06
5 HU Dun, ZHANG Li Ying, FENG Yi Pu (Institute of Materia Medica, Chinese Academy of Medical Sciences, Peking Union Medical College, Beijing 100050);Effect of dl 3 n butylphthalide on memory disturbance induced by focal cerebral ischemia in rats[J];CHINESE JOURNAL OF PHARMACOLOGY AND TOXICOLOGY;1997-01
6 Xiong Jie(Xiong J) and Feng Yipu(Feng YP) (Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050);EFFECTS OF 3 n BUTYLPHTHALIDE ON THE INCREASE OF INTRACELLULAR CALCIUM IN NEURONS SUBJECTED TO HYPOXIA AND HYPOGLYCEMIA AND ITS MECHANISMS[J];ACTA PHARMACEUTICA SINICA;1999-12
7 WT4”,5BZ]XIONG Jie, FENG Yi Pu (Institute of Materia Medica, Chinese Academy of Medical Science, Peking Union Medical College, Beijing 100050, China) [WT4”,5HZ];THE PROTECTIVE EFFECT OF BUTYLPHTHALIDE AGAINST MITOCHONDRIAL INJURY DURING CEREBRAL ISCHEMIA[J];ACTA PHARMACEUTICA SINICA;2000-06
8 YP Feng,D Hu andLYZhang(Institute of Materia Medica ,Chinese Academy of Medical Sciences and Peking Union Medical College ,Beijing 100050);EFFECT OF DL-BUTYLPHTHALIDE(NBP)ON MOUSE BRAIN ENERGY METADOLISM IN COMPLETE BRAIN ISCHEMIA INDUCED BY DECAPITATION[J];ACTA PHARMACEUTICA SINICA;1995-10
9 JF Lin and YP Feng(Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College,Beijing 100050);EFFECT OF DL-3-N-BUTYLPHTHALIDE ON DELAYED NEURONAL DAMAGE AFTER FOCAL CEREBRAL ISCHEMIA AND INTRASYNAPTOSOMES CALCIUM IN RATS[J];ACTA PHARMACEUTICA SINICA;1996-03
10 Xu Haoliang(Xu HL) and Feng Yipu(Feng YP) (Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050);EFFECTS OF 3 n BUTYLPHTHALIDE ON PIAL ARTERIOLES IN FOCAL CEREBRAL ISCHEMIA RATS[J];ACTA PHARMACEUTICA SINICA;1999-03
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