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《JOURNAL OF CLINICAL CARDIOLOGY》 1999-08
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The effect of perindopril and felodipine extended release tablets on platelet activation and fibrinolytic activity in elderly patients with essential hypertension

Zou Guangtao  Wang Mingyin  Ma Zhimin et al ( Department of Internal Medicine, Zhoukou Prefecture People′s Hospital, Zhoukou 466000)  
Objective:To evaluate the effect of perindopril and felodipine extended release tablets on platelet activation and fibrindytic activity in elderly hypertensives.Method:Radioimmunoassay and spectrophotometric assay were used to examine the levels of platelet alpha granule membrane protein (GMP 140), tissue type plasminogen activator (t PA) and its inhibitor (PAI 1), angiotensinⅡ(ANGⅡ) and aldosterone (Ald) after treatment with perindopril (group Ⅰ,n=28) and felodipine extended release tablets (group Ⅱ,n=27) in 55 elderly patients with essential hypertension (EH) of stage Ⅰ to Ⅱ. Result:After treatment, GMP 140 and PAI 1 activity significantly reduced (P 0.01 , 0.05 respectively), but t PA activity significantly increased (P 0.05 ) in both group. AngⅡ and Ald significantly reduced (P 0.01 ) in group Ⅰ. No obvious changes of Ang Ⅱ and Ald were found in group Ⅱ. Before treatment, a positive correlation was noted between the levels of GMP 140 and PAI 1 (r= 0.407 6 ,P 0.01 ),GMP 140 and AngⅡ(r= 0.416 2 ,P 0.01 ),as well as PAI 1 and AngⅡ(r= 0.423 7 ,P 0.01 ) in the 55 EH patients.Conclusion:These findings indicate that decreasing the levels of AngⅡ is one of the mechanism of perindopril to inhibit platelet activation and to improve fibrinolytic activity in elderly EH patients,but the effect of felodipine extended release tablets to inhibit platelet activation and to improve fibrinolytic activity has no relation to renin angiotensin system.
【CateGory Index】: R544.1
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【Co-references】
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【Secondary References】
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