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《JOURNAL OF CLINICAL CARDIOLOGY》 1999-10
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Effect of perindopril on the balance of nitric oxide and endothelin in blood of patients with essential hypertension

Zhang Jiancheng Guang Ruijin Ru Lihong et al (Fujian Provincial Institute of Cardiovascular Disease,Fuzhou 350001)  
Objective:To evaluate the effects of perindopril on the balance of NO/ET in blood of patients with essential hypertension (EH).Method:The alteration of balance of NO/ET were respectively observed by Griess method,radioimmunoassay in all subjects,including 25 control subjects and 30 EH patients before (EHB) and after (EHA) one month therapy with perindopril (EH group).Result:The ratio of NO/ET was significantly lower in EHB group than in control group (P 0.01 ),and higher in EHA group than in EHB group (P 0.05 ).Mean blood pressure (MBP) was higher in EHB group than in control group (P 0.01 ),but lower in EHA group than in EHB group (P 0.01 ).The ratio of NO/ET was inversely related to MBP in all groups (control:r= -0.581 P 0.01 ,EHB:r= -0.35 P 0.05 ,EHA:r= -0.505 P 0.01 ).Conclusion:The results suggest that the imbalance of NO/ET is present in blood of patients with EH,which negatively related to MBP,may play an important role in sustaining and developing of hypertension.Perindopril reverses the imbalance of NO/ET and speculate that this action may be an important aspect of its antihypertensive mechanism.
【Fund】: 福建省自然基金!( C930 17)
【CateGory Index】: R544.1
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【Citations】
Chinese Journal Full-text Database 1 Hits
1 Zhang Jiancheng, Lu Lihong, Hu Xizhong,et al(Department of Cardiology,Fujian Provincial Institutefor Cardiovascular Diseases,Fuzhou,350001);Alteration of the Balance of NO/ET in Blood of Patients with Essential Hypertension[J];JOURNAL OF FUJIAN MEDICAL UNIVERSITY;1998-01
【Co-citations】
Chinese Journal Full-text Database 2 Hits
1 LIU Hai bo △, WANG Yu shan (Dept.of Emergency Medicine, The Second Hospital,Jilin University, Changchun 130041,China);The effect of perindopril on nitric oxide and angiotensin converting enzyme in serum of patient with essential hypertension[J];Journal of Norman Bethune University of Medical Science;2002-05
2 HUANG Jun, LIU Chang-hui, ZHANG Li-jun. Department of Geriatrics, Renming Hospital of Wuhan University, Wuhan 430060, China;Plasma Levels of sICAM-1, ET and NO in Elderly Patients with Essential Hypertension and the Effect of Perindopril on Them[J];Journal of Chinese Physician;2004-04
【Co-references】
Chinese Journal Full-text Database 4 Hits
1 LI Xi, PENG Jian, LU Wu-sheng, MENG Su-rong, ZHANG Yun-kun (Department of Caridology,Department of Ultrasonography, Nanfang Hospital, First Military Medical University, Guangzhou 510515, China);Effects of perindopril on blood pressure and cerebral blood flow in elderly patients with essential hypertension[J];Journal of First Military Medical University;2001-05
2 Tang Jiarong, Liu Zhengxiang, Zhou Qiang, Zhang Jing *, Wu Cuihuan ** , Liang Qianshen (  Department of Cardiology, Tongji Hospital, Department of Neurobiology,  Department of Pathology, Tongji Medical University, Wuhan, 430030;EFFECTS OF PERINDOPRIL ON VASCULAR HYPERTROPHY IN RAT WITH EXPERIMENTAL HYPERTENSION[J];CHINESE JOURNAL OF HISTOCHEMISTRY AND CYTOCHEMISTRY;1999-02
3 Wang Zhonglin Li Yifu Zhou Yuming (Department of Cardiology, The Second Affiliated Hospital, Hunan Medical University, Changsha 410008);EFFECTS OF PERINDOPRIL ON HYPERTENSION, SERUM ANGIOTENSIN I CONVERTING ENZYME ACTIVITY AND URING LEVEL OF N ACETYL BETA D GLUCOSAMINIDASE[J];BULLETIN OF HUNAN MEDICAL UNIVERSITY;1997-03
4 Zou Guangtao  Wang Mingyin  Ma Zhimin et al ( Department of Internal Medicine, Zhoukou Prefecture People′s Hospital, Zhoukou 466000);The effect of perindopril and felodipine extended release tablets on platelet activation and fibrinolytic activity in elderly patients with essential hypertension[J];JOURNAL OF CLINICAL CARDIOLOGY;1999-08
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