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《Journal of Clinical Cardiology》 2009-04
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Effects of LOX-1 on ox-LDL inducing Fractalkine signaling in vascular smooth muscle cell and the protective effect of Apocynum venetum

LI Jianwei1 ZHENG Yang2 JIN Yuanzhe1 (1Department of Cardiology,Fouth Affiliated Hospital of China Medical University,Shenyang,110032,China;2Department of Cardiology,First Hospital Jilin University)  
Objective:To investigate the role of LOX-1 in the process of ox-LDL inducing the expression of FKN in Vascular smooth muscle cell(VSMC) and the protective effects of Apocynum venetum.Method:VSMC were incubated in vitro and the expression of LOX-1,FKN mRNA were detected by ELISA and RT-PCR.Result:ox-LDL can induce the high expression of FKN in VSMC,while carrageenan,the inhibitor of LOX-1 and Apocynum venetum can inhibit the expression of FKN obviously(P0.05).Conclusion:In the inflammation of VSMC,the expression of FKN were induced by ox-LDL through the LOX-1 pathway and could be inhibited by Apocynum venetum at the high concentrations(0.8 g/L).Apocynum venetum might have the effects of anti-inflammatory and anti-atherosclerosis.
【CateGory Index】: R543.5
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