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《Chinese Journal of Clinical Gastroenterology》 2002-03
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The Characteristics of Intestinal Flora in Patients with Liver Cirrhosis and its Therapeutic Observation

Niu Ming hua, Zou Xiao ping, Gao Feng, et al Department of Gastroenterology, Ankang Railroad Hospital, Xi an 725000  
Purpose: To observe the characteristics of intestinal flora in patients with liver cirrhosis and to evaluate the therapeutic effect on these bacteria. Methods: Microculture technique and common primer PCR were employed to identify the features of intestinal flora in 177 patients with liver cirrhosis and 30 healthy controls. The bacterial morphological examination was used to observe the formation and aggregation of bacteria in the stool and several drugs were used to evaluate the therapeutic effect on these bacteria. Results: The aggregation rate of bacteria in the stool was significantly higher in patients with liver cirrhosis than in the healthy controls(51.4% vs 7.8%,P0 01), furthermore, the generative ability, mobility and resistance to antibiotics remarkably increased in patients with liver cirrhosis. After the patients with liver cirrhosis were treated with bifid triple viable capsule, duphalac and combined both of them, the aggregation rates were 60.1%, 51.2% and 10.7% respectively, significantly decreased as compared with placebo 100%(P0 05). Conclusion: The aggregation rate of bacteria, the generative ability, activity, resistance to bacteria were significantly higher in patients with liver cirrhosis than in healthy controls. Bifid triple viable capsule and duphalac, as medicine for regulation of the intestinal flora, have better effects than antibiotics.
【CateGory Index】: R575.2
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