Clinical efficacy and safety of intravenous calcium for osteoporosis

YE Sheng-kai;CHEN Hai-ying;REN Xia;WEN Jie;DU Ying;MIAO Xin-ying;LI Xue;ZHANG Ru;YU Li;ZHANG Bi-ying;WANG Bing-bing;Department of Endocrinology,the 967th Hospital of PLA;  

Objective:To analyze the clinical efficacy and safety of intravenous calcium for osteoporosis(OP).Methods:A total of 963 OP patients were divided into control group,oral calcium group,intravenous calcium group and combination calcium group.Calcium treatments lasted for more than 2 years.Medical record was collected to compare demographic data,changes in bone mineral density(BMD),improvements of pain and function,changes of biochemical parameters,OP parameters and intima-media thickness(IMT),fractures,rate of total arthroplasty and tooth loss,incidence of cardiovascular and cerebrovascular diseases,incidence of lumbar disc herniation(LDH),infection and tumors.Results:There was no group difference at baseline(P0.05).In the four groups,the incidence of liver and kidney abnormalities,gallstones and kidney stones,coronary heart disease(CHD),heart failure,cardiovascular calcification,hypercalcemia and tumors,and IMT had no statistically significant difference after2 years of calcium treatment(P 0.05).Compared to the control group,the BMDs of the lumbar vertebrae and hip in the oral calcium group were significantly increased(P 0.05),alkaline phosphatase(ALP),visual analogue scale(VAS),Oswestry disability index(ODI),and incidence of fractures in the oral calcium group were significantly decreased(P0.05).There were no statistically significant differences between the rate of total arthroplasty and tooth loss,incidence of arrhythmia(premature beats,tachycardia,atrial fibrillation),LDH,infection and cerebral infarction of the control group and oral calcium group(P0.05).Compared to the control group and the oral calcium group,the BMDs of the lumbar vertebrae and hip in the intravenous calcium group and combination anti-osteoporosis group were significantly increased(P 0.01),ALP,VAS,ODI,incidences of fractures,rate of total arthroplasty and tooth loss,incidence of arrhythmia,LDH,infection and cerebral infarction in the intravenous calcium group and combination anti-osteoporosis group were significantly decreased(P0.01).There was no significant difference between the intravenous calcium group and combination calcium group(P0.05).Conclusion:Long-term administration of oral calcium or intravenous calcium is effective for the treatment of OP,and the clinical efficacy of intravenous calcium is better.

【CateGory Index】： R580

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