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《Clinical Medical Journal of China》 2001-04
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Correlation of Peritumoral Brain Edema and Vascular Endothelia Growth Factor (VEGF) mRNA Expression

Zhang Yu Cui Yaoyuan Hu Hua, et al (Department of Neurosurgery, Zhongshan Hospital, Fudan University, Shanghai 200032)  
Objective: To investigate the relationship between VEGF mRNA and peritumoral brain edema. Methods: Tumor tissue obtained from surgery was studied in 37 patients with meningioma and 28 patients with astrocytoma. VEGF mRNA was analyzed by semiquantitative RT-PCR. Peritumoral brain edema was evaluated by EI according to CT and MRI image prior to surgery. Results The expression of VEGF mRNA was significantly positive related to EI by correlation analysis both in meningioma group ( r=0.619, P 0.01) and in astrocytoma group( r=0.874, P 0.01). Conclusion:VEGF played an important role in the peritumoral brain edema of meningioma and astrocytoma.
【CateGory Index】: R739.41
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