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A random study of xiaoaiping injection combined with chemotherapy on the treatment of advanced non-small cell lung cancer

WANG Wen-yu,ZHOU Yun,ZHANG Xiao-ju,GAO Tian-hui,LUO Zhi-fen,LIU Ming-yue.Department of Medical Oncology,Henan Province People's Hospital,Zhengzhou 450003,China  
Objective:To evaluate and compare the efficacy and safety of xiaoaiping injection combined with chemotherapy and chemotherapy alone on the treatment of patients with advanced non-small cell lung cancer(NSCLC).Methods:Patients with advanced NSCLC were randomly divided into trial group(27 patients)and control group(29 patients).Chemotherapy with TP regimen was given to the all patients.Meanwhile,a regimen of 80ml/d xiaoaiping injection was given from the lst to 7th days on the chemotherapy cycle in the trial group as well as the control patients received chemotherapy alone.Twenty-one days were as a cycle and all patients with 2 cycles.Results:The response rate was 63.0%(17/27) in the trial group and 51.7%(15/29) in the control group(P0.05).The KPS score after treatment was 86.20±9.65 in the trial group as well as 80.11±8.91 in the control group,and the difference of improvement was significant(P0.05).NK cells decreased(P0.05)in control group and it changed slightly in treatment group.The adverse effects related to xiaoaiping injection were mild and didn't need any treatment.Conclusion:Xiaoaiping injection combined with chemotherapy are better than chemotherapy alone on the treatment of NSCLC.It can increase the sensitivity to chemotherapy and improve the quality of life and NK cells immunity function of the patients with advanced NSCLC.
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