Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Clinical Oncology》 2009-11
Add to Favorite Get Latest Update

Clinical obseration of Xiaoaiping combined with concurrent chemoradiotherapy in advanced nasopharyngeal cancer

ZHOU Wei-bing,HE Feng-jiao,JIANG Wu-zhong,FU jia.Department of Oncology,Xiangya Hospital Central-South University,Changsha 410008,China  
Objective:To observe the outcome of combining Xiaoaiping injection treatment with concurrent chemoradiotherapy(CCRT) on locally advanced nasopharyngeal cancer.Methods:From July 1,2007 to October 30,2007,a cohort of 69 patients with pathologically proved advanced nasopharyngeal carcinoma(92 in Fuzhou in stages Ⅲ,and ⅣA period of poorly differentiated squamous cell carcinoma of nasopharynx) was randomly divided into two groups.One group of 39 patients were treated with Xiaoaiping combined with CCRT simultaneously(Xiaoaiping treatment group),and the other group of 30 patients was treated solely with CCRT(control group),both of the groups adopted a program of conventional radiation therapy and chemotherapy TP(docetaxel 75mg/m2 d1,28;cisplatin 100mg/m2 d2).In Xiaoaiping treatment group,CCRT combined injection Xiaoaiping 40ml +5%glucose injection 250 ml,d1-d7.Weekly observation during treatment of oropharyngeal reactions,skin reactions,side effects such as bone marrow suppression(leukopenia).After CCRT for two weeks,patients with functional status and immune function points were observated according to KPS.After radiotherapy for 3 and 12 months,disease remmision rate(CR+PR) was evaluated.Results:In the short-term results it showed that Xiaoaiping treatment group responded better to control group.The performance status of Xiaoaiping treatment group,according to KPS questionnaire,was higher than that of control group.As to the side effects of oral ulcers,throat pain associated with oropharyngeal dysphagia and other symptoms,and the skin reactions on the neck and leukopenia response,Xiaoaiping treatment group suffered less than control group,which showed clear statistical significance(P=0.037 5).Conclusion:Xiaoaiping injection combined with CCRT in the treatment of locally advanced nasopharyngeal cancer can enhance the effectiveness,reduce the clinical symptoms resulting from the treatment and improve immune function effectively,improve patients' physical wellbeing and promote the quality of life in locally advanced nasopharyngeal.
【CateGory Index】: R739.63
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved