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《Chinese Clinical Oncology》 2010-03
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Status and progress of basic researches of elemene injection for anti-tumor

TANG Xiu-hong,QIN Shu-kui,XIE Tian.PLA Cancer Center,the Affiliated 81 Hospital of PLA,Nanjing University of Chinese Medicine,Nanjing 210002,China  
Elemene is one of terpenes compound,which extracted from zingiberaceae Wenyujin (curcuma aromatica salisb1).β-elemene is as the main ingredient of elemene injection that also contains a small amount of γ-and δ-elemene and other terpenoids.Through pre-clinical experiments and clinical trials in 1994 elemene injection is an application as a national second-class new drug of anti-tumor.Over the years,further basic researches related to elemene injection,which fully shows the drug for a variety of tumor cells were killed with a significant inhibitory effect,as well as inducing tumor cell apoptosis and differentiation,reversal of multidrug resistance of tumor cells and anti-metastases.Combined with radiotherapy and chemotherapy,it has sensibilization,attenuation improve immunity,and mild toxicities.
【Key Words】： Elemene Anti-tumor effect Mechanism Fundamental research
【CateGory Index】： R730.5
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