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《Chinese Clinical Oncology》 2011-07
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Expression of β_Ⅲ-tubulin and the clinical significance in gastric cancer

FAN Ying-rui,LU Bin-bin,YANG Chun,WANG Ke-ming.Department of Oncology,the Second Affiliated Hospital of Nanjing Medical University,Nanjing 210011,China  
Objective To explore the relationship between the expression of βⅢ-tubulin and clinical characteristics and prognosis of patients with gastric cancer.Methods Expression of βⅢ-tubulin in 58 paraffin-embedded gastric cancer and 53 matched paracancer tissues were analyzed by immunohistochemistry method.The patients' clinical data and survival time were collected and analyzed.Results High expression rate of βⅢ-tubulin was 70.69%(41/58)in gastric cancer tissues and 64.15%(34/53) in matched paracancer tissues(P0.05).Expression of βⅢ-tubulin was not related to age,gender,pathological type,stage,status of lymph node metastasis and tumor invasion grade(P0.05).In 41 patients with complete follow-up data,the survival rate of patients with high βⅢ-tubulin expression was 52.0%,while patients with low βⅢ-tubulin expression was 43.8%.There was no significant difference between them(P0.05).Conclusion Overexpression of βⅢ-tubulin was not significantly associated with age,gender,patholigical type,aggressive tumor behavior(stage,status of lymph node metastasis and tumor invasion grade) and prognosis in gastric cancer.
【Fund】: 南京医科大学科技发展基金面上资助项目(07nmum039)
【CateGory Index】: R735.2
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