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《Chinese Journal of Clinical Pharmacy》 1999-04
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Clinical pharmacokinetic and pharmacodynamic studies of carboplatin in the patients with cancer

Gao Yunlua , Zhu Yuyun, Jin Jingshun, et al (Shandong Provincial Institute for Biological Products,Taian 271  
AIM: To study the clinical pharmacokinetics and pharmacodynamics of carboplatin. METHODS: Twelve patients with cancer were treated with carboplatin 400 mg in 10% glucose injection 250 ml intravenous drip for 60 min. Serum levels of carboplatin were determined by reversed-phase high performance liquid chromatography. The data were processed with method of residuals. RESULTS: The average serum levels of carboplatin (c) was (55. 10±13. 00)mg/L at the end of intravenous drip. The half-life (T1/2β) of carboplatin was (143. 09 ± 49.36)min. The clearance (CD was (45. 17± 16. 68)ml/min. The average of c were (61.03 ± 9.28) and (52. 14 ± 12. 77 ) mg/L , T1/2β(191. 27 ± 26. 92 ) and (119.00 ± 35. 31)min (P0. 01), and CL (31.42±6.79) and (52. 04 ± 15. 97)ml/min (P0. 05) in effective and ineffective groups, respectively. After intravenous drip, the serum levels of carboplatin in effective group were higher than ineffective one from 2 to 10 hours (P 0. 05). CONCLUSION: The individual variation of serum levels of carboplatin is shown significantly in patients with cancer after intravenous drip. The therapeutic effects of carboplatin is related with its serum levels and parameters of elimination.
【CateGory Index】: R969
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【References】
Chinese Journal Full-text Database 1 Hits
1 ZHU Yu-Yun, GAO Yun-Hua, PANG Guang-Li, et al (Department of Clinical Pharmacology, Taishan Medical College, Shandong Taian 27 1000);Pharmacokinetics of carboplatin after endoscopic intratumor administration in t he patients with upper digestive tract carcinoma[J];Chinese Journal of Hospital Pharmacy;2001-09
【Citations】
Chinese Journal Full-text Database 2 Hits
1 SHAN Shun-Lin(Huaiyin 2nd People's Hospital, Jiangsu Province, Huaiyin 223002);Carboplatin vs cisplatin-combined chemotherapy for advanced malignant tumors[J];;1995-05
2 GAO Yun-Sheng CHEN Wen-Tan~a QU Jun-Qing (Department of Pharmacology,Taishan Medical College,Tai'an 271000;α~Department of Surgical Oncology,Taian Central Hospital);REVERSED-PHASE HPLC DETERMINATION OF CARBOPLATIN IN HUMAN SERUM[J];Chinese Journal of Pharmaceuticals;1992-04
【Co-references】
Chinese Journal Full-text Database 5 Hits
1 LI SuZHANGLi LIAO Hai JIANG Wen-Qi(Medicine department, Tumor Hospitual of Sun-Sen University, Guangzhou 510060);Estimation the Area under the Total Carboplatin Plasma Concentration Versus Time (A UC) by HPLC[J];The Chinese Journal of Clinical Pharmacology;2002-04
2 Qin Qingliang ,Xin Li,Tong Ruitiang,Dept.of Oncology ,Affiliafed Hospital of Taishan MidicaI College)Hu Jiangong,Bu LingXiu(Dept.of Medicine ,Affiliated Hospital of Taishan Midical College);THE PRIMARY STADIES UNDER ENDOSCOPY INJECT CARBOPLATIN FOR 20 CASES ADVANCED STOMACH CANCER[J];JOURNAL OF TAISHAN MEDICAL COLLEGE;1995-03
3 GAO YunSheng, ZHU YuYun, GAO YunHua,LI Juan, QIN QingLiang, QIU YuFang,TONG RuiTian(Dept of Pharmacology, Taishan Medical College, Taian271000);Comparison of antitumor effects and pharmacokinetics of carboplatinadministered intratumorally and intravenously in mice with tumor[J];CHINESE PHARMACOLOGICAL BULLETIN;1999-02
4 LI Jie,WANG Jing-ping, ZHOU Li-li, KONG Yong-xia, LIU Shu-zhe, WANG Ling(Henan Tumor Institute, Zhengzhou 450003, China; Henan Tumor Hospital, Zhengzhou 450003, China);Determination of carboplatin and pseudouridine in the human serum by HPLC[J];Chinese Pharmaceutical Journal;2005-09
5 Liu Yunying Sun Yan Sun Yuhai,et al.(Department of Medical Oncology,Cancer Hospital & Institute,Chinese Academy of Medical Sciences);CLINICAL PHARMACOLOGICAL STUDY ON DOMESTICALLY-PRODUCED CARBOPLATIN IN CANCER PATIENTS[J];Chinese Journal of New Drugs;1993-06
【Secondary References】
Chinese Journal Full-text Database 1 Hits
1 XIE Zhi-hong,YE Li-ka,ZHOU Long-shu,TANG Bo(Dept.of Pharmacy,The Second Affiliated Hospital of GuangZhou Medical College,Guangdong Guangzhou 510260,China);HPLC determination of carboplatin concentration in human plasma[J];Chinese Journal of Hospital Pharmacy;2009-06
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