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《Chinese Journal of Clinical Pharmacy》 1999-04
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Clinical pharmacokinetic and pharmacodynamic studies of carboplatin in the patients with cancer

Gao Yunlua , Zhu Yuyun, Jin Jingshun, et al (Shandong Provincial Institute for Biological Products,Taian 271  
AIM: To study the clinical pharmacokinetics and pharmacodynamics of carboplatin. METHODS: Twelve patients with cancer were treated with carboplatin 400 mg in 10% glucose injection 250 ml intravenous drip for 60 min. Serum levels of carboplatin were determined by reversed-phase high performance liquid chromatography. The data were processed with method of residuals. RESULTS: The average serum levels of carboplatin (c) was (55. 10±13. 00)mg/L at the end of intravenous drip. The half-life (T1/2β) of carboplatin was (143. 09 ± 49.36)min. The clearance (CD was (45. 17± 16. 68)ml/min. The average of c were (61.03 ± 9.28) and (52. 14 ± 12. 77 ) mg/L , T1/2β(191. 27 ± 26. 92 ) and (119.00 ± 35. 31)min (P0. 01), and CL (31.42±6.79) and (52. 04 ± 15. 97)ml/min (P0. 05) in effective and ineffective groups, respectively. After intravenous drip, the serum levels of carboplatin in effective group were higher than ineffective one from 2 to 10 hours (P 0. 05). CONCLUSION: The individual variation of serum levels of carboplatin is shown significantly in patients with cancer after intravenous drip. The therapeutic effects of carboplatin is related with its serum levels and parameters of elimination.
【CateGory Index】: R969
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