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《Chinese Journal of Clinical Pharmacy》 2001-06
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Mechanisms of Atractylodes macrocephala enhancing gastrointestinal motility

Zhu Jinzhao 1, Zhang Jie 1, Xu Qizeng 1, Zhang Zhijian 1, Leng Enren 2, Chen Dongfeng 2 ( 1Department of Gastroenterology,Fuzhou General Hospital, Nanjin Military Area, Fuzhou 350025; 2Department of Gastroenterology, Daping Hospital, The  
AIM: To explore the prokinetic mechanism of Atractylodes macrocephala by observing the distribution changes of AChE and SP positive nerve of gastrointestinal tract in rats. METHODS: Thirty two wistar rats were randomly divided into Atractylodes macrocephala group and control group. After the rats were given 2 5 g/kg of Atractglodes macrocephala decoction for 1 h, distribution of AChE positive nerve in antro jejunal myoplexus was showed by histochemistry. The immunohistochemistry was used to investigate the distribution of SP positive nerve in antro jejunum. RESULTS: Distributions of AChE positive nerve in antro jejunal myoplexus and SP positive nerve in antro jejunal myoplexus and jejunal submucosa of rats increased significantly after Atractylodes macrocephala decoction was given. CONCLUSION: The increased distributions of AChE and SP positive nerve in gastrointestinal tract may play some role in the prokinetic effects of Atractylodes macrocephala .
【Fund】: 重庆市自然科学基金资助项目 ( 960 18)
【CateGory Index】: R285
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