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《Chinese Journal of Clinical Pharmacy》 2010-06
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Effect of pH regulators on the oral bioavailability of scutellarin in rats

LI Yuping~1,ZHANG Libin~1,TIAN Feifei~2,WENG Weiyu~2(1 Department of Pharmacy,Shanghai Pulmonary Hospital, School of Medicine,Tongji University,Shanghai 200433,China;2 School of Pharmacy,East China University of Science and Technology,Shanghai 200237,China)  
AIM To evaluate the effect of pH regulators on the oral bioavailability of scutellarin in rats.METHODS The plasma concentration of scutellarin,the primary active ingredient in breviscapine,was determined by an HPLC-UV method.Rats received the following 3 treatment regimens at an oral dose of 40 mg·kg~(-1)(calculated with reference to scutellarin):(A) breviscapine suspension without pH regulators;(B) pre-administration with sodium bicarbonate -citric acid buffer(pH 6.2),then breviscapine suspension without pH regulators;(C) breviscapine suspension adjusted to pH 6.2 with sodium bicarbonate-citric acid buffer.RESULTS The relative bioavailability to treatment regimen A was 183.1%and 162.4%for treatment B and C,respectively.No significant difference in AUC_(0→t) between treatments regimen B and regimen C was observed.In treatment regimen A,about 1-2 h of lag time was observed for each rat, while scutellarin was absorbed rapidly and reached the first peak concentration within 15 min in treatment regimen B and regimen C.The profile of the solubility of scutellarin versus pH showed that scutellarin was poorly soluble at low pH and the solubility rose as the pH increased.CONCLUSION The pH value is an important influencing factor in absorption of scutellarin after oral administration.Pre-administration and co-administration of pH regulators to elevate gastric pH could increase the solubility of scutellarin,which result in shorter lag time and higher bioavailability in rats.
【CateGory Index】: R285.5
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Chinese Journal Full-text Database 5 Hits
1 WANG Yan-fang,ZHANG Yu,HAO Guan-zhong(Third Affiliated Hospital of Inner Mongolia Medical College,Baotou 014010,China);Make Progress OF Clinical Application In Breviscapine[J];Journal of Diseases Monitor & Control;2010-03
2 Wang Hong 1,Chen Jimin,Zhang Qingmin Department of Pharmacy, Shenyang Pharmaceutical University,Shenyang 110015;A Study on the Absorption Kinetics of Baicalin in Rats′ Stomachs and Small Intestines in vitro[J];JOURNAL OF SHENYANG PHARMACEUTICAL UNIVERSITY;2000-01
3 Yang Limei1,3,Gu Jun2,3,Lin Mingjian3,Ge Qiang3,Li Lingzhi2,3(1.Pharmacy college,Tianjin Medical University,Tianjin 300070;2.Tianjin Key Laboratory of Occupational and Environmental Hazards Biomarkers,Tianjin 300193;3.Department of Pharmaceutical Chemistry,Medical Collage of Chinese People's Armed Police Forces,Tianjin 300162);Advances in research on breviscapine[J];Tianjin Pharmacy;2010-01
4 DING Jiang Sheng 1, ZHANG Jun Shou 2 1Kunming Pharmaceutical Cooperation.(Group), Kunming 650100, China 2Department of Pharmaceutics,China Pharmaceutical University,Nanjing 210009, China;Absorption of Breviscapine in Small Intestine of Rat[J];Journal of China Pharmaceutical University;2003-01
5 GE Qing Hua 1, ZHOU Zhen 1, ZHI Xiao Jin 1, MA Li Li 1, CHEN Xiu Hua 2 (1. National Pharmaceutical Engineering Research Center; 2. Shanghai Institute of Pharmaceutical Industry, Shanghai 200437);Pharmacokinetics and Absolute Bioavailability of Breviscapine in Beagle Dogs[J];Chinese Journal of Pharmaceuticals;2003-12
Chinese Journal Full-text Database 10 Hits
1 SUN Li-jing1,WANG Xuan-shen1,L Hui-yi1,TIAN Yan2(1.Departement of Pharmacy,the Second Affiliated Hospital of Dalian Medical University,Dalian 116027,China;2.College of Pharmacy,Dalian Medical University,Dalian 116044,China);Progress of research on gastrointestinal transit pharmacokinetics in Chinese herbal compound preparations[J];Journal of Dalian Medical University;2008-06
2 HUANG Zhi-jian,YANG Li-ying,CHEN Qiang,JIANG He-ji(College of Animal Science,Fujian Agriculture and Forestry University,Fuzhou,Fujian 350002,China);Pharmacokinetics of Compound Yin-chen Granule in mice[J];Journal of Fujian Agriculture and Forestry University(Natural Science Edition);2007-05
3 YU En-xi1,WANG Fang2,JIAN Zhi-hong2(1.Dept.of Pharmacology,Hubei Institute for Drug Control,Wuhan,Hubei 430064,China;2.People's Hospital of Wuhan University,Wuhan,Hubei 430060,China);Protective effects of breviscapine phosphatidylcholine complex against cerebral ischemia reperfusion injury in rats[J];Journal of Guangdong College of Pharmacy;2007-02
4 YANG Qiu-xia1,MA Fu-jia2,ZHANG Lan-lan3,CHEN Jian-ming11.Department of Pharmaceutics,School of Pharmacy,Second Military Medical University,Shanghai 200433,China2.Department of Pharmacy,No.455 Hospital of PLA,Shanghai 2000523.Modern TCM Institute,Tasly Pharmaceutical Co.,Ltd,Tianjin 300402;Absorption characteristics of silybin-phospholipid complex by rat intestine[J];Academic Journal of Second Military Medical University;2009-11
5 CHANG Jin-hua,YU Hai-long,LIU Cui-zhe(The Key Lab of Chinese Medicine Research and Development,Institute of Chinese Materia Medica,Chengde Medical College,Hebei Chengde 067000,China);STUDY ON THE PHARMACOKINETICS OF BAICALIN IN NEW SAN-HUANG TABLET IN RATS[J];Journal of Chengde Medical College;2010-04
6 ;Pharmacokinetics Research on Baicalin of Yinhuang Granules in Big Rat Internal Body[J];Guiding Journal of TCM;2005-11
7 YANG Qiang 1,YANG Jun-yi 1,LI Si-cheng 2,ZHANG Ling-min 1 (1.West China School of Phamacy,Sichuan University,Chengdu 610041,China;2.Chengdu Yiping Medicine Science and Technology Development Co.Ltd,Chengdu 610045,China);The relative bioavailability of Breviscapine sustained-release tablets in Beagle dogs[J];West China Journal of Pharmaceutical Sciences;2004-03
8 HE Yan1,2,PAN Wei-san1(1.School of Pharmacy,Shenyang Pharmaceutical University,Shenyang,Liaoning,110160 P.R.China;2.Sustained and Controlled Released Preparartion Center of Guangzhou Pharmaceutical Industry Research Institute,Guangzhou,Guangdong,510240 P.R.China);Preparation and in vitro release of breviscapin two-layer osmotic pump tablets[J];West China Journal of Pharmaceutical Sciences;2009-01
9 LI Jian1),DONG Yan-qin1),LI Chen1),ZHANG Xuan1),WANG Yun-feng2),WANG Dian-hua1) (1)Yunnan Pharmacological Laboratory of Natural Products,Kunming Medical University,Kunming Yunnan 650031;2)Dept. of Otolarygology,EENT Hospital of Shanghai Medical College of Fudan University,Shanghai 200032,China);Effects of Breviscapine Liposomes for Pulmonary Delivery System on Expression of Protein Tissue Factor in Acute Lung Injury in Rats[J];Journal of Kunming Medical University;2008-03
10 SHEN Teng~1 YU Yunqiu~2 WENG Weiyu~1 LI Ni~2 HUANG Zhaochang~3 CAI Jia~1 HUANG Jianming~2 1 Department of Pharrnaceutics, 2 Department of Pharmaceutic Analysis,School of Pharmacy,Fudan University,Shanghai 200032,China; 3 Kunming Pharmaceutical Corporation Ltd.,Kunming 650100,China;Absolute bioavailability of breviscapine sustained release tablet in rabbit[J];Chinese Journal of Clinical Pharmacy;2008-01
China Proceedings of conference Full-text Database 3 Hits
1 LIU Hui,YANG Xinggang, NIE Shufang, LI Ding, PAN Weisan (School of Pharmacy, Shenyang Pharmaceutical University ,Shenyang 110016,China);Studies on the absorption kinetics of danshensu in rat’s intestines[A];[C];2006
2 YOU Hai-sheng1,DONG Ya-lin1, XING Jian-Feng2, ZHANG Chun-ling3, WANG Mao-yi1 (1.Department of pharmacy, The first affiliated hospital of Medical School, Xi’an Jiaotong University, Xi’an, 710061, China; 2 .Xi’an Jiaotong University of Medical School Xi’an, 710061, China;.3.Red cross hospital Xi’an, 710061, China );The pharmacokinetic and tissues distribution study of scutellarin in rat[A];[C];2006
3 SONG Yan,ZHANG Hong-mei,MA Jian-jian,CHE Qing-ming,LI Chang-ling (School of Pharmaceutical Sciences,Peking University Health Science Center,Beijing100191,China);Protection of Scutellarein on cerebral ischemia in rats[A];[C];2010
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 ZHANG Xiao bing, PENG Dai yin, ZHU Man fang,ZHOU Ya Qiu, LIU Qing yun (Department of Pharmacy, Anhui College of Traditional Chinese Medicine,Anhui Hefei 230038,China);Protective Effect of Breviscapine Dropping Pill Against Focal Cerebral Ischemia Reperfusion Injury in Rats[J];Journal of Anhui Traditional Chinese Medical College;2003-01
2 TAO Jiemei,ZHANG Fengxiao,SUN Lijun,et al.The People's Hospital of Hebei Province,Shijiazhuang 050051;The therapeutic effect of Dengzhanhuasu on rheumatoid arthritis.[J];Hebei Journal of Traditional Chinese Medicine;2005-04
3 WU Jing, ZHONG Hui ju, SUN Zhi xiang, et al. (Department of Endocrinology, Xiangya Hospital, Central South University, Changsha 410008, China);Efficacy of erigeron on diabetic peripheral neuropathy[J];Bulletin of Hunan Medical University;2002-04
4 SHI Xiao-qin,HAN Yan-mei,LI Na,ZHANG Ming-yan(Hebei Medical College for Continuing Education,Baoding 071000,China);Protection of breviscapine against lipid peroxidation damage of liver[J];Academic Journal of Pla Postgraduate Medical School;2005-06
5 DONG Yan-qin1),LI Jian1),ZHANG Lu-han2),ZHANG Xuan1),LI Chen1),WANG Dian-hua1)(1)Yunnan Pharmacological Laboratory of Natural Products,Kunming Medical College,Yunnan Kunming 650031;2)Yunnan Food and Drug Administration,Yunnan Kunming 650101,China);Therapeutic Effect of Pulmonary Delivery of Breviscapine on Rat with Acute Lung Injury Induced by Lipopolysaccharide[J];Journal of Kunming Medical College;2007-06
6 ZHOU Zengtong, ZHANG Shuilong, HUA Li, ZHONG Wenjing, JIN Zhigui, DING Ruiyu(Department of Oral Medicine, Shanghai Ninth People's Hospital, School of Stomotology, Shanghai Second Medical University, Shanghai 200011,China);Study of Resisting Leukoplakia Canceration and Angiogenesis of Herba Erigerontis[J];SHANGHAI JOURNAL OF STOMATOLOGY;2000-02
7 Zhou Qingsong Jiang Xuehua Li Kejia Fan Xinxing(West China School of Pharmacy,Sichuan University,Chengdu 610041,China);The Synthesis,Characterization and in Situ Intestinal Absorption of Different Molecular Weight Scutellarin-PEG Conjugates[J];Journal of Biomedical Engineering;2006-02
8 CUI Jian-mei,WU Song ( Department of Development,Institute of Materia Medica,Peking Union Medical College,Chinese Academy of Medical Sciences ,Beijing 100050,China);THE ADVANCE ON THE RESEARCH OF BREVISCAPINE[J];Natural Product Research and Development;2003-03
9 XIA Ling-Ling, WEI Wei, LIN Hui,ZHOU Dian, QIAN Hao, ZHAO Min, WU Yong-Gui (Dept of Infectious Diseases,the First Affliated Hospital, Anhui Medical University,Hefei 230022);Experimental study on protective effect of breviscapine in the liver of diabetic rats[J];Chinese Pharmacological Bulletin;2004-06
10 JIANG Xue hua *, LI Su hua, LAN Ke, YANG Jun yi, ZHOU Jing (West China School of Pharmacy, Sichuan University, Chengdu 610041, China);Study on the pharmacokinetics of scutellarin in dogs[J];Acta Pharmaceutica Sinica;2003-05
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