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《Journal of Labour Medicine》 2004-05
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Screening Estrogenicity of Cadmium Using Uterotrophic Assay

RONG Shun-xing~1,WANG Ning~1,JIN Tai-yi~(1*),ZHOU Yuan-ling~2,SHEN Li-jun~1,ZHONG Xian-jiu~2 (1.Occupational Health Department,Public Health School of Fudan University,Shanghai,200032; 2.Occupational Disease Control Department of Jin Shan Hospital,Fudan University,Shanghai,200032)  
To screen estrogenicity of cadmium and compare the relationship between the uterus wet weight and blotted weight in uterotrophic assay and estimate the function of the index in uterotrophic assay. SD rats were administrated with different dose of estrogen (0,30,100,300,1 000,3 000,10 000 ng/kg bw)and cadmium(0,25,50,75,100,200 μg/kg bw)subcutaneously. The uteruses wet weight and blotted weight were measured after administrating constantly for 3 days. Compared with control group,uterus weight increased with dose-depedent fashion in both the estrogen groups and the cadmium groups. The conspicuous difference in blotted weight appeared in a higher dose group. In estrogen group,wet weight increased significantly in 30ng/kg bw group(P0.05),and blotted weight appeared significant difference in a higher dose group (100 ng/kg bw)(P0.05).Cadmium group has the similar pattern as estrogen group whose wet weight increased significantly in lower dose(75 μg/kg bw),and blotted weight in higher dose(100 μg/kg bw).Sap in uterus lumen increased following the increasing of dose in estrogen group,but in cadmium group,it only increased in lower dose groups. [Conclusion] Cadmium can increase the rats' uterus weight.
【Fund】: 国家 973项目 (编号 :2 0 0 2CB51 2 90 0 )
【CateGory Index】: R114
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1 Tang lingfang, Chen Yanmeg, Zhang Zhenling, Songling, Yang Yongnian, Feng Zhiying Department of Toxicology, Nanjing Medical University, Nanjing 210029;INFLUENCES OF CHLOROPAZINE,NIMODIPINE AND THEIR COMBINATON ON THE TOXIC EFFECTS OF CADMIUM ON LIVERS AND KIDNEYS OF MICE[J];CARCINOGENESIS, TERATOGENESIS AND MUTAGENESIS;1999-06
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