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《Journal of Labour Medicine》 2005-01
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Uterotrophic Assay of Acrylonitrile in Rats

WANG Ning,RONG Shun-xing,ZHOU Yuan-ling,ZHONG Xian-jiu,JIN Tat-yi (1.School of public Health,Fudan University,Shanghai 200032,China; 2.Jinshan Hospital,Fudan University,Shanghai 200540,China)  
Objective To investigate the estrogenic effect of acrylonitrile(AN) by the classic uterotrophic assay in rats. Acrylonitrile was injected subcutaneously at the doses of 0,10,15,25,40 and 60 mg/kg,once a day for 3 days,to ovaeriectomized Sprague-Dawley(SD) rats.Ethynylestradiol(EE) was also injected subcutaneously at a dose of 0.001 mg/kg as a positive control.All rats were killed 24 h after the last administration.The wet or blotted uterine weights,kidney and liver weights of rats were recorded. There were essentially no differences in the wet or blotted uterine weights between the control and any of the AN-treated groups(P0.05).The positive control ethynylestradiol(0.001 mg/kg per day) showed a significant effect using this assay protocol(P0 05).There was no excessive systemic toxicity in this assay except for slightly increased liver weight in the highest AN-treated group(P0 05). [Conclusion] Uterotrophy has not been observed in ovariectomized rats treated subcutaneously with AN up to 60 mg/kg.
【Fund】: 国家 973计划 (编号 :2 0 0 2CB51 2 90 5)
【CateGory Index】: R114
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