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《Journal of Labour Medicine》 2005-01
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Uterotrophic Assay of Acrylonitrile in Rats

WANG Ning,RONG Shun-xing,ZHOU Yuan-ling,ZHONG Xian-jiu,JIN Tat-yi (1.School of public Health,Fudan University,Shanghai 200032,China; 2.Jinshan Hospital,Fudan University,Shanghai 200540,China)  
Objective To investigate the estrogenic effect of acrylonitrile(AN) by the classic uterotrophic assay in rats. Acrylonitrile was injected subcutaneously at the doses of 0,10,15,25,40 and 60 mg/kg,once a day for 3 days,to ovaeriectomized Sprague-Dawley(SD) rats.Ethynylestradiol(EE) was also injected subcutaneously at a dose of 0.001 mg/kg as a positive control.All rats were killed 24 h after the last administration.The wet or blotted uterine weights,kidney and liver weights of rats were recorded. There were essentially no differences in the wet or blotted uterine weights between the control and any of the AN-treated groups(P0.05).The positive control ethynylestradiol(0.001 mg/kg per day) showed a significant effect using this assay protocol(P0 05).There was no excessive systemic toxicity in this assay except for slightly increased liver weight in the highest AN-treated group(P0 05). [Conclusion] Uterotrophy has not been observed in ovariectomized rats treated subcutaneously with AN up to 60 mg/kg.
【Fund】: 国家 973计划 (编号 :2 0 0 2CB51 2 90 5)
【CateGory Index】: R114
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【Co-citations】
Chinese Journal Full-text Database 6 Hits
1 LU Yi,LU Hai-xia,WANG Hong-hai,YE Lin(Department of Occupational and Environmental Hygiene,School of Public Health,Jilin University,Changchun 130021,China);Effects of bisphenol A on reproductive function in young male mice[J];Journal of Jilin University(Medicine Edition);2008-04
2 CUI Jin\|shan\+*,YANG Yan\|kai,FU Shou\|lin,et al (\+* Department of Toxicology,Shenyang Medical College,Shenyang 110031 China);Effect of Acrylonitrile Exposure on Male Sexual Hormone[J];Industrial Health and Occupational Diseases;2001-03
3 CUI Jin\|shan\+*,FU Shou\|lin,YANG Yan\|kai,et al (\+* Department of Toxicology,Shenyang Medical College,Shenyang 110031 China);Effects of Acrylonitrile on Reproductive Functions in Male Mice[J];Industrial Health and Occupational Diseases;2001-03
4 DUAN Zhi\|wen,ZHANG Yu\|min,LI Hai\|shan,et al (Department of Toxicology,Shenyang Medical College,Shenyang 110031 China);Effects of Acrylonitrile on Reproductive and Endocrine System of Female Rats[J];Industrial Health and Occupational Diseases;2001-03
5 XIAO Wei~*,LIU Xiao-ning(~* School of Radiation Medicine & Public Health,Suzhou University,Suzhou 215007 China);Effects of Acrylonitrile on Sex-maturity of Male Mice[J];Industrial Health and Occupational Diseases;2006-03
6 ZHONG Xian-jiu, WU Xin, ZHOU Yuan-ling, HUANG Jian-shu, JIN Tai-yi (Jinshan Hospital, Medical Center, Fudan University, Shanghai 200540, China; School of Public Health, Fudan University, Shanghai 200032, China);Effects of Acrylonitrile on Gene Expression of Androgen Binding Protein and Inhibin in Testes of Spraque-Dawley Rats[J];Journal of Labour Medicine;2005-05
【Co-references】
Chinese Journal Full-text Database 3 Hits
1 ZHENG Guang,ZHOU Zhi_jun ,DAI Xu_feng,et al (School of Public Health,Fudan university,Shanghai200032,China);Mice Uterotrophic Assay to Detect the Estrogenic Effects of Six Common Used Organophosphrus Pesticides[J];Carcinogenesis,Teratogenesis and Mutagenesis;2004-04
2 FU Yuan -hui,CHEN Xiac -yu,WU Yi - ming;Proliferation of endometrium inmice exposed to mercury chloride[J];Henan Journal of Preventive Medicine;2005-04
3 TONG Jun- wang, LI Jun, FAN Xue-yun, YAO San-qiao, Wang Ying(The Department of Prevention, North China Coal Medical College, Hebei Province, Tangshan 063000, China);Screening for Estrogenic Acitivities for Three Pyrethroids with Uterotrophic Assays[J];Journal of Labour Medicine;2005-04
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