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《Journal of Environmental & Occupational Medicine》 2007-04
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The Effect of PPD on Bone Marrow Cell Mutation in Mice

WANG Hui-yang College of Biology and Technology,Jinzhong College,Yuci,Shanxi 030600,China; ZHU Pei-liang College of Life Science of Technology,Guangxi University,Nanning,Guangxi,530004,China  
[Objective]To investigate the effect of p-phenylenediamine(PPD)on bone marrow polychromatic erythrocyte (PCE)mutation in mice.[Methods]50 mice were divided into five groups at random.0.2 ml PPD in different dosage(215.00 mg/kg,107.50 mg/kg,53.75 mg/kg and 26.88 mg/kg respectively)were injected intraperitoneally daily for 2 days in 4 different test groups of mice.0.2 ml normal saline was injected in the control group only.The number of micronucleus in PCE of bone marrow were measured after treated with this hair dye and the number of comet and its tail length were determined using single-cell gel eiectrophoresis(SCGE).[Results]It is found that the PPD could increase the micronucleus rate obviously and a dose-effect relationship between PPD and micronucleus rate existed.[Conclusion]PPD had strong mutagenic effect on bone marrow PCE mutation in mice.
【CateGory Index】: R114
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