A Review of Mutagenicity,Carcinogenicity and Toxicokinetics of Hair Dyes
ZHOU Yong-gui,LI Zhen-guan(Shanghai Center for Disease Control and Prevention,Shanghai 200336,China)
A large section of the oxidative hair dyes and a part of aniline derivatives and its oxidative products are mutagenicity. The carciongenicity studies in feed suggest that a part of aniline derivatives have induced bladder and liver carcinoma etc in rats and mice,but found no evidence of carcinogenicity in dermal carcinogenicity test. The result of epidemiological studies suggest that safety and carcinogenicity among oxidative hair dye users have no strong evidence so far,but occupational exposure might increased carcinoma frequency,which a summary estimate is median. The systemic percutaneous absorption rates of aniline derivatives were less than 1%,the absorption values 10mg for one time,more than 80% is excreted by man in the urine.
【CateGory Index】： R114