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《Physical Testing and Chemical Analysis(Part B:Chemical Analysis)》 2007-09
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FAAS Investigation of Therapeutic Effect of Chelating Agents on Cd,Ca,Fe,Zn in Testis of Acutely Cd-Infected Mice

CHEN Min XIE Ji-min YAN Yong-sheng (College of Chemistry and Chemical Engineering,Jiangsu University,Zhenjiang 212013,China)  
For purpose of developing new antidotes for Cd-infection,a FAAS method for the determination of Cd,Ca,Fe and Zn in testis of Cd-infected mice was established.The mice were infected by injection of CdCl_2 solution into the abdominal cavity(2.5 mg·kg~(-1))and the mice of control group were injected with plysiological saline.Determination results showed that in testis of the CA-infected mice,concentration of Cd,Ca,Fe,Zn was significantly increased,compared to the controlled group(p0.05).Several chelating agents were selected as the antidote candidates for the therapeutic effect investigation.They are N-p-hydroxy-methyl-benzyl-D-glcamine di- thioearbamate(HBGD),N-benzyl-D-glucamine di-thiocarbamate(BGD),diethyl-dithiocarbamate(DDTC),2,3- dimercaptopropanol(BAL)and ethylene diamine tetra acetic acid(EDTA).The chelating agent was also injected into the abdominal cavity(0.400 mmol·kg~(-1))as the therapy.Experimental findings verified that after 30 min of thesapeutic injection,the chelating agents,with exception of EDTA,significantly decrease the concentrations of CA,Ca,Fe,Zn(p0.05),and after 24 h of therapeutic injection,HBGD,BGD and DDTC display a notable effect of the decrease in Cd,Ca Fe,Zn concentrations.Considering the self toxicity of the chelating agents,it is suggested that HBGD and BGD are the better antidotes for Cd-infection.
【Fund】: 江苏省青蓝工程新世纪学科带头人基金及江苏省教育厅自然科学基金(00KJB330003)资助。
【CateGory Index】: R96
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