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《Zhejiang Clinical Medical Journal》 2008-06
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The expression of nuclear factor-kappa B(NF-кB) 、serum interleukin-8(IL-8) and interleukin-10(IL-10) in rat model of severe acute pancreatitis

Jin MuDan,et al  
Objective To investigate the expression of nuclear factor-kappa B(NF-кB),serum interleukin-8(IL-8) and interleukin-10(IL-10) in severe acute pancreatitis(SAP) in rats.And to investigate the roles of activated nuclear factor-kappa B(NF-κB) and serum IL-8 and IL-10 in SAP.Methods 40 Wistar rats were randomly divided into normal control group(Sham operation group) and model group(SAP group).There were 20 rats in each group.Levels of serum amylase,IL-8,IL-10 and activated NF-κB in the pancreatic tissue were detected 24 hours after operations.Results The levels of IL-8 and IL-10 in serum SAP were significantly higher than those in normal control group.Activated NF-κB was enhanced in SAP group compared with Sham operation group.Conclusions IL-8,IL-10 and NF-κB play an important role in severe acute pancreatitis.There was activated NF-κB at the early stage of severe acute pancreatitis.
【CateGory Index】: R576
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