Research Progress of Selaginellin and the Anti-tumor Activity of Selaginella

Zeng Qinghai 1,Tu Chao 2,Fan Fan3,Chen Yaolei?4,Yin Jun 3*,Zen Yong5*(1 Third Xiangya Hospital,Central South University,Changsha,Hunan,410013,China;2 Second Xiangya Hospital,Central South University,Changsha,Hunan,410013,China;3 Xiangya Hospital,Central South University,Changsha,Hunan,410008,China;4 The Department of Cerebral Surgery,General Hospital of Chongqing Iron and Steel Co.,Ltd,Dadukou,Chongqing,400081,China;5Pharmary Department of Hunan provincial tumor hospital,Changsha,Hunan,410013,China)  

Plants in Selaginella Genus are in abundance on the earth,and can be applied in many medical situations.Recently there are a lot of new discoveries and researches being done in exploring the resources,active components,and pharmaceutical effects of Selaginella nationally and internationally.During all these discoveries,the anti-tumor activity of Selaginella attracts more and more scholars,and Bisflavones in Selaginellin are considered the chief effective ingredient.Cytotoxicity,induction of apoptosis,blocking the invasion of tumor cells,transfer are the main mechanisms of pairs of flavonoids which plays anti-tumor effect.Selaginellin isolated in recent years was a new type of carbon skeleton of compounds,in addition to its antioxidant activity,recently its cytotoxicity have been found playing the role of anti-tumor.This article provides a general review for the research progress and pharmaceutical effects of Selaginellin,anti-tumor activity of Selaginella,and its mechanisms in the last few years.

【Key Words】： Selaginella Anti-tumor Bisflavones Selaginellin
【Fund】： 国家自然科学基金项目资助(81201730);; 湖南省卫生厅科技计划项目资助(132011-091)
【CateGory Index】： R285

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