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《Anti-tumor Pharmacy》 2018-06
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Effects of Shuyu Pill on Anxiety and Depression of Patients with Advanced Breast Cancer Treated by Chemotherapy

ZHU Ying;XING Yuqing;GAO Hong;PAN Yuzhen;PAN Lin;Oncology Department, the Affiliated Hospital of Liaoning University of Traditional Chinese Medicine;  
Objective To explore the effects of Shuyu pill on anxiety and depression in patients with advanced breast cancer treated by chemotherapy. Methods Eighty-eight patients with advanced breast cancer diagnosed in our hospital were selected and divided into observation group(48 cases) and control group(40 cases) according to different treatment methods. The control group was given conventional chemotherapy, while the observation group was treated with Shuyu pill on the basis of treatment of control group. All patients had been treated for three cycles. The TCM-related symptom scores, occurrence of toxicities and side effects, the scores of self-rating anxiety scale(SAS) and self-rating depression scale(SDS) and quality of life scores were analyzed and compared between the two groups. Results After treatment, the TCM symptom scores of the two groups were significantly lower than those before treatment(P0.05). And the score of the observation group were also lower than that of the control group(P0.05). The incidence of side effects including gastrointestinal reaction, bone marrow suppression, alopecia and liver function injury in the observation group was 18.8%, but was 57.5% in the control group, having significant difference between the two groups(P0.05). After treatment, the scores of anxiety and depression in the two groups were significantly lower than those before treatment(P0.05). And the SAS and SDS scores were also significantly lower in the observation group than in the control group after treatment(P0.05). The physical, psychological, social and mental scores of the observation group after treatment were significantly higher than those of the control group(P0.05). Conclusions The application of Shuyu pill in the chemotherapy of advanced breast cancer can relieve the anxiety and depression, reduce the occurrence of side effects, improve the symptoms of traditional Chinese medicine and improve the quality of life of the patients.
【Fund】: 辽宁中医药临床学(专)科能力建设项目(2013-Lnzyxzk-01)
【CateGory Index】: R273
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