Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Lingnan Journal of Emergency Medicine》 2008-03
Add to Favorite Get Latest Update

Study the Influence of Salvia Miltiorrhiza for Enteral Nutrition Praeparatum to Intestinal Mucosa Endothelial Cell Apoptosis in S-MODS Model Rats

LIU Xiao-rong, REN Xin-sheng ICU,Tianjin Economic Technology Development District Area Hospital,Tianjin,300457  
Objective:To study the influence of salvia miltiorrhiza for enteral nutrition praeparatum to intestinal mucosa endothelial cell apoptosis in S-MODS model rats, and to explore a new treatment to prevent S-MODS. Methods: 70 Wistar rats were randomly divided into four groups: control group (n=10), model group (n=20), nutrition fibre group (n=20) and salvia miltiorrhiza for enteral nutrition group (n=20). The experiment period was 12 days. They were given Sodium Chloride, Sodium Chloride, nutrition fibre and salvia miltiorrhiza independently by intragastric administration for EN every day for 11 days. On the fourth day, sodium chloride was administered intravenously in normal group and endotoxin 3 mg/kg was administered intravenously in other groups. Blood routine was measured at 24 hours before and after giving the endotoxin. At the end of experiment, blood routine was measured. We use Paraffin imbedding chip when experiment completed. TUNREL method was used to detect intestinal mucosa endothelial cell apoptosis. Results: The model succeed by clinical manifestation,blood routine and pathology. We observed that compared with other groups after injection endotoxin 24 hours, clinical symptom was improved, blood routine recuperated in salvia miltiorrhiza for enteral nutrition group at the end of experiment. Blood leucocyte count and apoptotic index in salvia miltiorrhiza for EN group were lower than model group and nutrition fibre group at the end of experiment(P﹤0.05). Conclusions: Salvia miltiorrhiza for enteral nutrition could prevent gut function damage,protect intestinal mucosa and significantly decrease apoptotic. Salvia miltiorrhiza for enteral nutrition also could also relive the inflammatory response.
【CateGory Index】: R285.5
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Citations】
Chinese Journal Full-text Database 4 Hits
1 Xiu-Qing WU, Hong WANG, Mei SUN, Qing-Jie L U··, Zhuo ZHOU. Department of Pediatrics, Second Hospital of China Medical University, Shenyang 110004, China;lntestinal epithelial apoptosis and Caspase-3 expression in rats with endotoxemia[J];The Chinese Journal of Contemporary Pediatrics;2005-02
2 LIU Ke-xuan1,WU Wei-kang1,ZHU You-kai3,LIU Chui-liang4,SUN Hui-lan 2,ZHAO Ming-qi2 (1.Dept of Anesthesiology,the First Affiliated Hospital, 2.Institute of Integr ated Tradition Chinese and Western Medicine; 3.Dept of Pathology,Basic Medical College of Sun Yat-sen University,Guangzhou 5 10080,China; 4.Dept of Anesthesiology,the 2nd Affilliated Hospital of Guangzhou Tradition Med icine University,Guangzhou 510120,China);Effects of sini decoction on intestinal mucosa cell apoptosis and its ceramide mechanism after intestinal ischemia reperfusion in rats[J];Chinese Pharmacological Bulletin;2005-02
3 HUANG Fu-chun 1, FAN Yu 2,LI Hua 3(1.Department of Gastroenterology, Luohe Second Hospital of Henan Province, Luohe 462000, China; 2.Institute of Oncology, the Second Affiliated Hospital, Medical College of Zhejiang University, Hangzhou 310009,China; 3.Department of Pathology, School of Basic Medical Sciences, Fudan University, Shanghai 200032, China);Effect of Radix Salviae Miltiorrhizae on Tumor Necrosis Factor-α and Activity of Nuclear Factor κB of Hepatic Stellate Cells of the Rat[J];Herald of Medicine;2005-02
4 XU Guang-lin, YU Shu-qin(Center of Drug Research and Development, College of Life Science, Nanjing Normal University, Nanjing, 210097, China);Protection of endotoxin injury with antioxidants[J];Chinese New Drugs Journal;2005-02
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 LIU Xiao-rong,XU Jie,REN Xin-sheng,WANG Jing (Intensive Care Unit,Tianjin Economic Technology Development District Hospital,Tianjin 300457,China);Study of the protective effect of salvia miltiorrhiza ennoblement for enteral nutrition on intestinal mucosa in MODS model rats[J];Parenteral & Enteral Nutrition;2009-04
2 WANG Li-Jie, LIU Chun-Ying, SUN Mei, LU Qing-Jie. Department of Pediatrics, Second Clinical College, China Medical University, Shenyang 110004, China;Role of platelet activating factor in the injury of intestinal immuno-barrier function in young rats[J];Chinese Journal of Contemporary Pediatrics;2006-01
3 WU Xiu-Qing, SHU Lin-Hua, SUN Mei, WANG Hong, GAO Hong. Department of Internal Medicine, Shenyang Children′s Hospital, Shenyang 110032, China;Effect of glutamine on apoptosis of the small intestine in young rats with endotoxemia and its mechanism[J];Chinese Journal of Contemporary Pediatrics;2006-06
4 LI Dong,DAI Li-li,YU Bin-bin,JIANG Zhong-hua(Department of Gastroenterology,Second Affiliated Hospital,Chongqing Medical University,Chongqing 400010,China);Tanshinol induces proliferation,apoptosis and NF-κB activation in cultured rat hepatic stellate cells after IL-1β inducement[J];Acta Academiae Medicinae Militaris Tertiae;2009-08
5 WANG Wei-wei ZHANG Jin-yuan HAN Guo-feng HUANG Jian No.455 Hospital of PLA,Nephrology Center of Nanjing Military Area,Shanghai;Protective Effects of Salvia Miltiorrhiza on Renal Function in Rats of Aristolochic Acid Nephropathy[J];Shanghai Journal of Traditional Chinese Medicine;2007-08
6 Hong Wang Mei Sun,Department of Pediatrics,the Second Affiliated Hospital(Shengjing Hospital)of China Medical University,Shenyang 110004,Liaoning Province,China Zhuo Zhou,Department of Center Laboratory,the Second Affiliated Hospital(Shengjing Hospital)of China Medical University,Shenyang 110004,Liaoning Province,China;Effects of glutamine and dexamethasone on the expression of tumor necrosis factor alpha and matrix metalloproteinase 3 in rat liver with sepsis[J];World Chinese Journal of Digestology;2007-22
7 GUO Yun-liang1,YANG Xue-wei1,XIAO Sheng-yuan2,CHONG Zhuo1,LIN Wen-han2(1.Cerbrovascular Disease Institute,Affiliated Hospital of Medical Collage,Qingdao University,Qingdao Shandong 266003,China;2.State Key Lab of Natural and Biomimetic Drugs,Peking University,Beijing 100083,China);The regulating effect and mechanism of Sini decoction on vascular active substance in renovascular hypertensive rats[J];Chinese Pharmacological Bulletin;2008-01
8 WEI Qiao-zhen,WANG Lin-lin.(Department of Paediatrics,the First Affiliated Hospital of Guangxi Medical University,Nanning 530021,China);Infection and the Gastrointestinal Dysfunction[J];Medical Recapitulate;2008-09
9 ZHANG Xu1,2,ZHANG Ru-xue2, TU Hong-hai3,JIA Zheng-ping2(1.Pharmacy College, Lanzhou University,Lanzhou 730000, Gansu,China; 2. Base of Clinical Pharmacology, Lanzhou General Hospital, Lanzhou Command, PLA, Lanzhou 730050,Gansu,China;3. Institute for Drug and InstrumentControl,Xinjiang Command, PLA, Wulumuqi 830063,Xinjiang,China);Advances in Studies on the Mechanism of Anti-hypoxia Pharmacological Effect of Traditional Chinese Drug Compound Recipe[J];Chinese Archives of Traditional Chinese Medicine;2007-09
10 ZHAO Jian-xue,LU Wei-ting,GUO Hai-yan(Department of Infectious Diseases,Jiangsu Province Hospital of TCM,Nanjing 210029);Effects of Shuanghuqinggan granule on serum levels of TNF-α,IL-6 and IL-10 in hepatic fibrosis induced by carbon tetrachloride in rats[J];Medical Journal of West China;2009-11
【Secondary Citations】
Chinese Journal Full-text Database 9 Hits
1 Yuan Taoxia;Zhang Jinsheng;Zhang Yue'e;Chen Qi(Department of Pathology, School of Basic Medical Sciences,Shanghai Medical University,Shanghai 200032);CULTURE OF RAT LIVER ITO CELLS AND THE OBSERVATION OF INHIBITORY EFFECT OF HEPARIN ON ITO CELLS[J];ACTA ATADEMIAE MEDICINAE SHANGHAI;1996-02
2 Duan Yili(Tianjin Hospital for Infectious Diseases, Tianjin 300192);Treating Chronic Hepatitis with Anti-fibrosis by Dan-shen[J];Gianjin Journal of Traditional Chinese Medicine;2002-01
3 ZHU Xiao Feng, ZHANG Xiao Shi, LI Zhi Min, YAO Yu Qi, LIU Zong Chao, XIE Bing Fen, ZENG Yi Xin (Cancer Center, Sun Yat sen University of Medical Sciences, Guangzhou 510060);Induction of apoptosis by ceramide in nasopharyngeal carcinoma cell line CNE 2[J];CHINESE PHARMACOLOGICAL BULLETIN;2000-02
4 LIU Ke-xuan 1,2, WU Wei-kang2, LUO Han-chuan2, ZHAO Ming-qi2, ZHAO Dan-yang2 ( 1 The First Affiliated Hospital, 2Institute of Integrative traditional Chinese and Western Medicine, SUN Yat-sen University, Guangzhou 510080, China);Effects of Sini decoction on the ultrastructure of small intestinal epithelial cells in rats with intestinal ischemia-reperfusion[J];Chinese Journal of Pathophysiology;2004-04
5 LIU Yan1, YANG Cheng-ti1, WU Wei-kang2, ZHAO Dan-yang2 (1. Department of Cardiovascular of the Second Hospital Affiliated to Lanzhou Medical College, Lanzhou 730000, China; 2. Institute of Integrated Traditional Chinese and Western Medicine, Sun Yat-sen University of Medical Sciences, Guangzhou, 510080, China);Study on Sini Decoction in treatment of hemorrhagic shock: mechanism relating to oxygen radical and nitro oxide[J];Chinese Traditional Patent Medicine;2003-05
6 Wu Weikang;Luo Hanchuan and Hou Can(Sun Yatsen University of Medical Sciences,Guangzhou 510089);In Vitro Experiment on Scavenging Oxy-radical and SuppressingMyocardial Lipid Peroxidation with Sini Decoction[J];CHINA JOURNAL OF CHINESE MATERIA MEDICA;1995-11
7 CAO Xiao_e,AN Le_bin,SUN Chun,et al. Department of Pathophysiology, Shanghai Medical College for Health Staff, Shanghai 200237, China;A Comparative Study on Apoptosis of Intestinal Mucosal Cells During Ischemia and Ischemia_ reperfusion Injury in Rats[J];Journal of Chinese Microcirculation;2002-03
8 YU Shiying;Ben Changen;Yang Meijuan;Zhao Liyun;Bai Jinwen(Histology & Embryology Department,Beijing University of Traditional Chinese Medicine Beijing 100029);Qauntitative cytochemical study of salvia root's effect on hepatocyte of fibrosis cultured in vitro[J];China Journal of Basic Medicine In Traditional Chinese Medicine;1996-06
9 TAN You wen, YIN Yu mei, YU Xue jun, et al The Zhenjiang Municipal Third People′s Hospital, Jiangsu (212003);Influence of Salvia Miltiorrhizae and Astragalus membranaceus on Hemodynamics and Liver Fibrosis Indexes in Liver Cirrhotic Patients with Portal Hypertension[J];Chinese Journal of Integrated Traditional and Western Medicine;2001-05
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved