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《Chinese Journal of Geriatric Heart Brain and Vessel Diseases》 2007-09
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Effect of Potentilla anserina L.on cardiomyocyte apoptosis induced by hypoxia

LI Jian-yu,LI Ling-zhi,GONG Hai-ying,et al (Department of Pharmacy,Medical College of Chinese People's Armed Police Forces,Tianjin 300162,China)  
Objective To study the effect of Potentilla anserina L.on apoptosis of cultured neonatal rat cardiomyocytes induced by hypoxia and its possible mechanism.Methods A model of hypoxia injury was established by using primary cultured myocytes of neonatal SD rats.Using HE staining,Hochest-PI staining and technique of transmission electron microscopy(TEM),the morphological changes of cardiac myocytes were observed.The mechanism was studied using immunohistochemical staining of P53 protein at molecular biological level.Results Compared with hypoxic model group and normal control group,the extract of Potentilla anserina L.in alcohol could significantly attenuate the injurious changes,such as swelling,fragmentation and condensation of nucleus and could downregulate the expression of P53 protein(P0.01).Conclusion Potentilla anserina L.has a notable attenuating effect on apoptosis of cardiomyocytes induced by hypoxia.This effect might be related to regulating the expression of P53 protein.
【Fund】: 国家自然科学基金(30672774)
【CateGory Index】: R285.5
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