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《Liaoning Journal of Traditional Chinese Medicine》 2007-03
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Influence of EELC on Vasoactive Fractions of Gastric Mucous Coat in Rats with Gastric Ulcer

WANG Hong-tao1,YE Yun1,XIAO Shun-lin1,HONG Chun-zan2(1.Pharmaceutical Department,The Affiliated Hospital of Luzhou Medical University,Luzhou 646000,Sichuan,China;2.Pharmaceutical Department,Yanbian University Medical College,Yanji 133000,Jilin,China)  
Objective:To observe the influence of(ethy 1 acetate extraction of L oniceracaerulea L.Var.edulis Turcz.Ex Herd,EELC) on vasoactive fractions of gastric mucous coat,including nitric oxide(NO),nitric oxide synthase(NOS) and endothelin(ET),in rats with gastric ulcer.Method:Okabe's acetous cauterization was used to establish the gastric ulcer model in rat.The model rats were given drugs respectively for 10 days and then the contents of NO、NOS and ET in peripheral tissues of gastric ulcer were detected.Results:The contents of NO and NOS in gastric tissues in different groups increased obviously compared with that of the model group(P0.01),and the content of ET in different groups decreased obviously compared with that of the model group(P0.01).Conclusion:EELC could increase remarkably the contents of NO and NOS in rat gastric tissues and decrease the content of ET.It may be the mechanism of EELC in the improvement of gastric ulcer healing in rats.
【CateGory Index】: R285.5
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