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《Liaoning Journal of Traditional Chinese Medicine》 2007-11
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Effects of Osthole on Serum Testosterone and the Testis Androgen Receptor(AR) in the Reproduction System Disturbance Mice

XIE Jin-xian1,WANG Nai-ping1,LI Ping1,LI Shang-qiu1,YUAN Juan-li2,LI Wei-neng1(1.Guangxi Traditional Chinese Medical University,Nanning 530001,Guangxi,China;2.Dept.of Pharmacology,Nanchang University Medical College,Nanchang 330006,Jiangxi,China)  
Objective: To investigate the effects of osthole on testosterone in serum and AR in the reproduction system disturbance mice. Methods: The reproduction system disturbance model was established by injecting cyclophosphamide in mice.The level of serum testosterone were determinded by the radio-immunoassay.AR was determined by immunohistochemistry.The sexual organ coefficents were calculated.Results: The high dose of osthole significantly increased the level of serum testosterone in the reproduction system disturbance mice and increased significantly the AR positive cells percentage of peritubular myoid cells.The low and high doses of osthole significantly increased the coefficients of seminal vesicle.Conclusions: Osthole could increase the level of serum testosterone and enhance expression of peritubular myoid cells AR in the reproduction system disturbance mice.
【Fund】: 广西科学研究与技术开发计划项目(桂科基0448061)
【CateGory Index】: R285.5
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