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Optimizing Prescription of CPP Modified Paclitaxel plus Tamoxifen Liposomes by Central Composite Design-Response Surface Method

WANG Jiao;WANG Yanhong;LIU Shuang;SONG Xiaoli;CHENG Lan;LI Xuetao;School of Pharmacy,Liaoning University of Traditional Chinese Medicine;  
Objective: To optimize the prescription of CPP modified paclitaxel plus tamoxifen liposomes by central composite design-response surface methodology. Methods: The CPP modified paclitaxel plus tamoxifen liposomes was prepared by film dispersion-ammonium sulfate gradient method. The mole ratios of EPC/CHOL,EPC/PEG2000-DSPE and EPC/paclitaxel were used as the independent variable,and the encapsulation efficiencies of paclitaxel and tamoxifen were used as the dependent variable. Results: The final optimal prescription of the liposomes was EPC/CHOL = 50: 1,EPC/PEG2000-DSPE = 5. 5: 1 and EPC/paclitaxel = 50: 1. The encapsulation efficiencies of the paclitaxel and tamoxifen were 95. 48%. Conclusion: Central composite design-response surface methodology can optimize the optimal formulation of CPP modified paclitaxel plus tamoxifen liposomes.
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