Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Chinese Journal of Clinical and Experimental Patholog》 2001-03
Add to Favorite Get Latest Update

Correlation between factor of cell proliferation and prognosis in nasopharnygeal carcinoma(NPC)

He Xia, 2Min Huaqing, 2Lin Zhongning, 2Wu Qiuliang, 2He Jiehua, 2He Jinghui, 2Feng Kaitao ( 1Department of Radiation Oncology,Jiangsu Tumor Hospital, Nanjing 210009; 2Sun Yat sen University of Medical Scien  
Purpose To evaluate the expression of cyclin D1, c erbB 2, Ki 67, PCNA in NPC, and to select the best prognostic factor in NPC. Method Expression of cyclin D1, c erbB 2, Ki 67, and PCNA was determined by S P immunohistochemical technique in 212 consecutive patients with nasopharyngeal carcinoma. Results The positive rate of expression of cyclin D1 was 81 25%. The intensity of the cyclin D1 expression had a positive relationship with the clinical stage the invasive extent of nasopharyngeal foci and the relapse rate in nasopharynx. There was a negative correlation between the intensity of cyclin D1 and the five years survival rate. The positive rate of expression of c erbB 2 was 95%. The intensity of the c erbB 2 expression had a positive relationship with the clinical stage, the relapse of nasopharyngeal foci, neck lymph node metastasis, and distant metastasis. With the increase of c erbB 2 expression, the five years survival rate decreased.The positive rate of expression of Ki 67 was 97%. Expression of Ki 67 had a positive relationship with clinical stage, nasopharyngeal recurrence and neck metastasis. The positive rate of expression of PCNA was 99%. Correlational analysis of cyclin D1, c erbB 2, Ki 67 and PCNA showed that although Ki 67 and PCNA did not seem to correlate, obvious correlation existed between the other factors. Multi factor analysis found that cyclin D1 and c erbB 2 were factors that strongly influence prognosis.Conclusions The factors of cell proliferation, cyclin D1 and c erbB 2, have high correlation with the prognosis of nasopharyngeal carcinoma. Patients with high expression of cyclin D1 and c erbB 2 should be treated with combination chemotherapy.
【CateGory Index】: R739.63
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【References】
Chinese Journal Full-text Database 2 Hits
1 PAN Min, HUANG Chang-jie, ZHAN Yong-zi, YIN-Dong, HUANG Jian-feng, WANG Xiang-ping, SHI Gui-ying, LI Dong-yunThird Affiliated Hospital of Guangxi Medical University, Nanning 530031, P.R.China;cerbB-2 expression and significance in patients with nasopharyngeal carcinoma[J];Chinese Journal of Cancer Prevention and Treatment;2007-13
2 HE Xia1,YE Yan-li2,LIN Zhong-ning3,et al.(1.Jiangsu Cancer Hospital,Nanjing 210009,China;2.Animal Experimental Center,Medical College,Sun Yat-sen University,Guangzhou 510089,China;3.Environmental Health Department of Health Collge,Sun Yat-sen University,Guangzhou 510089,China);Effect of Chemotherapy on Protein Expression of Cyclin D1 of Xenografted NPC in Nude Mouse[J];Journal of Oncology;2005-06
【Citations】
Chinese Journal Full-text Database 2 Hits
1 Jin Ou Yan Yahui Shen Ming Cheng Ruixue(Department of Pathology, Hunan Medical University, Changsha 410078);The relationship between C-erbB-2 expression with cell proliferativeactivity and prognosis of nasopharyngeal carcinomas[J];BULLETIN OF HUNAN MEDICAL UNIVERSITY;1998-03
2 Luo Jingwei,Xu Guozhen,Yang Weizhi,et al.Cancer Hospital,Pecking Union Medical College,Chinese Academy of Medical Science, Beijing 100021;Correlation between proliferating cell nuclear antigen (PCNA) expression and nasopharyngeal carcinoma( NPC)[J];CHINESE JOURNAL OF RADIATION ONCOLOGY;1997-03
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 PAN Zhi zhong, WAN De sen, ZHANG Chang qing, et al.1 Department of Abdominal Surgery of Cancer Center of Sun Yat sen University ofMedical Siences,Guangzhou 510060,P.R. China2 Laboratry Center of Cancer Hospital of Sun Yat sen University of M;Expression of p53,PCNA in colorectal cancer and its clinopathologicalcorrelation and prognostic significance[J];CHINESE JOURNAL OF CANCER;1999-05
2 GU Kang sheng1, WU Qiu liang2, HOU Jing hui2, WANG Bo3, GUAN Zhong zhen1* 1.Department of Internal Medicine, Cancer Center, Sun Yat sen University of Medical Sciences, Guangzhou 510060, P.R.China2.Department of Pathology, Cancer Center, Sun Yat sen;HER-2/neu Expression and Clinical Significance in Patients with Nasopharyngeal Carcinoma[J];Chinese Journal of Cancer;2001-08
3 MO Hao-Yuan1,ZHANG Chang-Qing2,FENG Kai-Tao2,ZHANG Feng1,HONG Ming-Huang1,SUN Zhe-Yu1 1.Department of Nasopharyngeal Carcinoma,cancer Center,Sun Yat-sen University,Guangzhou,Guangdong,510060,P.R.China 2.Research Department,Cancer Center,Sun Yat-sen University,Guangzhou,Guangdong,510060,P.R.china;Expression of P53 and PCNA in Nasopharyngeal Carcinoma and Their Relation with Clinical stage,VCA/IgA,EA/IgA,Radiation Sensibility,and Pognosis[J];Chinese Journal of Cancer;2004-S1
4 Zhou Yingqiong,Yao Tiejun,Li Fancai,Wei Huasheng,Hou Qiaoyan//Dept. of Pathology, Guilin Medical College, Guilin,541001;The Expression of p53 Protein in Nasopharyngeal Carcinoma[J];ACTA MEDICINAE SINICA;1998-05
5 HUANG Chang-jie,ZHAN Yong-zi,HUANG Jian-feng,WANG Xiang-ping,Li Dong-yun,PAN Min,BAO Wei-ying,LI Li,DENG Yan(Department of Oncology,the Third Affiliated Hospital,Guangxi Medical University,Nanning 530031,China);Expression and relativity of CerbB-2,COX-2 in nasopharyngeal carcinoma[J];Guangxi Medical Journal;2009-03
6 Wang Guangcai; Huang Shuwei; Liu Yisheng et al(Department of Pathology);Expression of P~(53) Protein in Astrooytoma and Its Relation with Proliferating Cell Nuclear Antigen[J];ACADEMIC JOURNAL OF GUANGZHOU MEDICAL COLLEGE;1997-02
7 LIN Shaomin,WEI Xiong,CAI Baizhen,et al,The Hainan Provincial people's hospital;Clinical significance of p53 and p21 proteins expression in nasopharyngeal carcinoma(NPC)[J];Hainan Medical Journal;2002-04
8 ZHANG Shao-wei,LIN Lian-xing,SHEN Jin-hui, et al (Department of Otolaryngology,Shantou Center Hospital,Shantou 515031,China);The Expression and Clinical Significance of nm23 and PCNA Gene Protein in Nasopharyngeal Carcinoma[J];Henan Journal of Oncology;2001-02
9 ZHOU Guang-yao 1,LIU Ya-feng 1,LUO Feng 2,et al. (1.Department of Otolaryngology,West China Hospital,Sichuan University,Chengdu 610041; 2.The Center of Biotherapy for Cancer,West China Hospital,Sichuan University,Chengdu 610041,China);A Study on the Relatinoship between the Cell Prolieration and Apoptosis in Nasopharyngeal Carcinoma[J];West China Medical Journal;2005-02
10 HUANG Jin, TAN Min, ZHU Yu-heng, LU Chang-qing, TAN Yan Changzhou No.1 Hospital, Changzhou 213003, P.R.China;Expressions of HSP70 and Ki-67 in nasopharyngeal carcinoma and the evaluation to prognosis[J];Journal of Qilu Oncology;2005-14
【Co-references】
Chinese Journal Full-text Database 10 Hits
1 GU Kang sheng1, WU Qiu liang2, HOU Jing hui2, WANG Bo3, GUAN Zhong zhen1* 1.Department of Internal Medicine, Cancer Center, Sun Yat sen University of Medical Sciences, Guangzhou 510060, P.R.China2.Department of Pathology, Cancer Center, Sun Yat sen;HER-2/neu Expression and Clinical Significance in Patients with Nasopharyngeal Carcinoma[J];Chinese Journal of Cancer;2001-08
2 HE Xia1, HONG Minghuang1,HE Youjian2,et al Department of Nasopharyngeal Carcinoma, Cancer Center, Sun Yatsen University of Medical Scieces, Guangzhou 510060,China;Preliminary study of new chemotherapy regimen and therapeutic strategy on distant metastatic nasopharyngeal carcinoma[J];CHINESE JOURNAL OF CANCER;1999-03
3 LI Heng-guo 1, ZHONG Xing 1, KANG Ju-ling 2, XIA Ming-han 2 (1. Dept. of Medical Imaging; 2. Dept. of Pathology, First Affiliated Hospital of Medical College, Jinan University, Guangzhou 510630, China);Expression of P53 and c-erbB-2 protein in nasopharyngeal carcinoma and their correlation with the clinical staging and recurrence[J];Journal of Jinan University(Natural Science & Medicine Edition);2002-02
4 SHI Hong-qi,LOU Shan-xian,LIU Qing-wei.Department of Pathology,Jinhua Municipal Central Hospital,Jinhua 321000,China;Significance of p16 and Cyclin D1 Expressions in Human Bladder Transitional Cell Carcinoma[J];Journal of Qilu Oncology;2003-11
5 SUN Yu cai,HU Guo hua,ZHU Jiang. Department of Otolaryngology,The First Affiliated Hospital of Chong Qing Medical University,Chongqing,400016;Expression of cyclin D1 in Laryngeal Carcinoma[J];The Practical Journal of Cancer;2003-01
6 ZHANG Jun, ZHANG Wei-yun (Department of Pathology, Guiyang Medical College, Guiynɡ 550004, China);Expression of eIF-4E, HER-2 and its correlation with LMP-1 and PCNA in nasopharyngeal carcinoma[J];Chinese Journal of Diagnostic Pathology;2005-03
7 YAN Jian, FANG Yan, JIAO Yan, et al. Cancer Center, Sun Yat-sen University of Medical Sciences,Guangzhou 510060, China;Significance of her2 oncogene expression in primary nasopharyngeal carcinoma[J];National Medical Journal of China;2001-15
8 Zhu Shuchai, Zhai Fushan, Yin Weibo,et al. Department of Radiotherapy , Fourth Hospital of Hebei Medical University, Shijiazhuang 050011;Effect of cyclin D1 protein expression on the prognosis of esophageal squamous cell carcinoma treated with preoperative radiotherapy[J];CHINESE JOURNAL OF ONCOLOGY;1998-02
9 ZENG Jun,ZHOU Yun Fong,GONG Ling ling,et al Department of Pathology and radiation Chemotherapy Hubei Medical University additional second hospital,Wuhan 430071,China;Association of Vascular Endothelial Growth Factor, C-erbB_2、p53 Expression in Nasopharyngeal Carcinoma[J];CANCER RESEARCH ON PREVENTION AND TREATMENT;2000-02
10 ZHANG Nan, WANG Li-hong, LI Chun-hua, et al The First Hospital of West China Medical University of Medical Sciences (Chengdu 610041)$$$$;THE EXPRESSION OF C-erbB-2,p16 AND nm23-H_1 PROTEIN IN TISSUES OF NASOPHARYNGEAL CARCINOMA AND THEIR RELATIONS WITH PROGNOSIS[J];Cancer Research and Clinic;2001-01
【Secondary References】
Chinese Journal Full-text Database 3 Hits
1 HUANG Chang-jie,ZHAN Yong-zi,HUANG Jian-feng,WANG Xiang-ping,Li Dong-yun,PAN Min,BAO Wei-ying,LI Li,DENG Yan(Department of Oncology,the Third Affiliated Hospital,Guangxi Medical University,Nanning 530031,China);Expression and relativity of CerbB-2,COX-2 in nasopharyngeal carcinoma[J];Guangxi Medical Journal;2009-03
2 LI Bei~1,ZHANG Lei~2,WANG Hui~3,HAO Jing~1,HU Dong-yan~1,LI Ming~1,WANG Xiu-wen~1(1.Department of Chemotherapy,Qilu Hospital of Shandong University,Jinan 250012,Shandong,China;2.Department of Urology,Second Hospital of Shandong University,Jinan 250033,Shandong,China;3.Department of Radiotherapy,Shandong Tumor Hospital,Jinan 250117,Shandong,China);Correlation between chemosensitivity and prognosis and abnormal expression of cyclin D1 and p27 in non-small cell lung cancer[J];Journal of Shandong University(Health Sciences);2006-09
3 YIMING Adilijiang1,GE Hai-liang2,ZHANG Hui-zhen2,SUZUKE Lalai3,XU Lei1 (1.Departement of Human Anatomy,Xinjiang Medical University,Urumqi 830011,China;2. Institute of Immunology,Medcine College of Shanghai Jiaotong Univer-sity,Shanghai 200025,China;3.Department of Pathology,Xinjiang Medical University,Urumqi 830011,China);The inhibitory effect of C225 alone or in combination with DDP on the growth of transplanted human cervical cancer in nude mice[J];Tumor;2009-01
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved