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《Chinese Journal of Clinical and Experimental Pathology》 2006-06
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Expression of S100A4 and E-cad in oral squamous cell carcinoma and their significance

CHEN Yong-feng~1,ZHANG Ling-da~2, CAO Li-yu~3( ~1Department of Stomatology, the First Affiliated Hospital of Bengbu Medical College, Bengbu 233004,China; ~2Department of Oral Dentofacial Surgery, ~3Department of Pathology, the First Affiliated Hospital of Anhui Medical University, Hefei 230022, China)  
Purpose To discuss the expression of S100A4 and E-cad in oral squamous cell carcinoma (OSCC) and their significance.Methods Expression of S100A4 and E-cad was detected by using immunohistochemical SP method in oral squamous cell carcinoma.Correlation between the expression and clinicopathological features was analyzed.Results Expression of S100A4 had positive correlation with lymph node metastasis (P0.05), and no correlation with histological grade(P0.05). Expression of E-cad had positive correlation with histological grade and negative correlation with lymph node metastasis(P0.05). Inverse relationship between S100A4 and E-cad expression was observed in oral squamous cell carcinoma(P0.05).Conclusions E-cad plays an important role in differentiation of OSCC. E-cad and S100A4 is closely related to invasion and metastasis of OSCC. Expression of S100A4 and E-cadherin is significantly associated with tumor progression in oral squamous cell carcinoma,which are valuable markers in predicting biological behavior and trend of metastasis in OSCC.
【CateGory Index】: R739.8
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【References】
Chinese Journal Full-text Database 1 Hits
1 WANG Di,GENG Jing-shu,CHENG Hui (Department of Pathology,The Third Clinical College,Harbin Medical University,Harbin 150081,China);Expressions of cyclooxygenase-2 and epithelial cadherin in squanmous cell carcinoma of cervix and the clinical significances[J];Journal of Harbin Medical University;2008-04
【Citations】
Chinese Journal Full-text Database 1 Hits
1 ZHOU Hai-kuan1, ZHAO Yong-bin2, ZHENG Shao-bin1, CHEN Tong1, MAO Xiang-ming1, QI Huan1, WU Rong-juan1 1Department of Urological Surgery, Nanfang Hospital, Southern Medical University, Guangzhou 510515, China; 2Department of Urological Surgery, General Hospital of Guangzhou Command, Guangzhou 510010, China;Association of S100A4 mRNA expression with differentiation and metastasis of renal cell carcinoma[J];Journal of First Military Medical University;2005-06
【Co-citations】
Chinese Journal Full-text Database 3 Hits
1 CHEN Yong-feng1,CAO Li-yu2,HUANG Quan-shun1,ZHANG Kai1(1.Department of Stomatology,The First Affiliated Hospital of Bengbu Medical College,Bengbu 233004;2.Department of Pathology,The First Affiliated Hospital of Anhui Medical University,Hefei 230022,China);Expressions of S100A4 protein in oral squamous cell carcinoma and its significance[J];Journal of Bengbu Medical College;2007-06
2 CHEN Xiang-li1, WANG Lian-cai2, ZHANG Wang-gang1, CHEN Xiao-yan3, SUN Zhong-min3 1Department of Hematology, Second Affiliated Hospital, Xi'an Jiaotong University, Xi'an 710004, China; 2Department of Surgery, 3Department of Respiratory Diseases, First Affiliated Hospital, Xi'an Jiaotong University, Xi'an 710061, China;Correlations of S100A4 and MMP9 expressions to infiltration, metastasis and prognosis of non-small cell lung cancer[J];Journal of Southern Medical University;2008-07
3 HU Hongjun 1) , YANG Kunpeng 2) , ZHANG Bin 2) , SU Yanhe 2) , YAN Donghai 2) , CUI Xinzheng 2) , LI Daoming 3) 1)Department of Thoracic Tumor Surgery, Xinxiang Central Hospital, Xinxiang 453000 2)Department of Thoracic Surgery, the Second Affiliated Hospital, Zhengzhou University, Zhengzhou 450014 3)Henan Key Laboratory of Tumor Pathology, Zhengzhou 450052;Expression of S100A4 and E-cadherin in human non-small cell lung cancer tissue[J];Journal of Zhengzhou University(Medical Sciences);2006-06
【Co-references】
Chinese Journal Full-text Database 3 Hits
1 Gu Huaping 1,Shang Peizhong 2,Ni Canrong 3 ( 1Department of Pathology, 2Department of Surgery, 251st Hospital of PLA,Zhangjiakou 075000; 3Department of Pathology, Changhai Hospital of Second Military Medical University, Shanghai 200433);Correlation of CD44v6 and E-cadherin expression with invasion and metastasis in colorectal carcinoma[J];Chinese Journal of Clinical and Experimental Pathology;2003-03
2 Wu Huijuan 1,Liu Shaoyang 1,Jiang Daqiong 1, Zeng Jun 2,Gong Lingling 2 ( 1Department of Gynecological Oncology, 2Department of Pathology, Zhongnan Hospital,Wuhan University,Wuhan 430071);Relationship of expression of cyclooxygenase-2 with p53 and E-cadherin expression in cervical carcinoma[J];Chinese Journal of Clinical and Experimental Pathology;2004-05
3 WANG Xi-mei~1,ZHAN Li~2,WU Yong-jun~3,SUN Lei~4,LIU Feng-jie~1,ZHANG Zhong~4 (~1Department of Basic Medicine,Huaihua Medical College,Huaihua 418000,China; ~2Department of Pathology,Dalian maternity hospital,Dalian 116027,China; ~3Department of Pathology,Affiliated First Hospital,Huaihua Medical College,Huaihua 418000,China;~4Center of Pathology,Dalian Medical University,Dalian 116027,China);Relationship of COX-2 expression with P27~(kip1) and MMP-2 in cervical adenocarcinoma using tissue microarray[J];Chinese Journal of Clinical and Experimental Pathology;2005-03
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