Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Journal of Luzhou Medical College》 2010-01
Add to Favorite Get Latest Update


Luo Linjie,et al Department of Respiratory Medicine,the First People's Hospital of Yibin City  
Objective:To investigate the changes of cell cycle distribution and apoptosis in lung adeno-carcinoma A549 cells before and after the STAT3 gene silencing and its significance. Methods:Before and after RNA interference (RNAi) technology silencing STAT3 gene expression in lung adenocarcinoma A549 cells ,the changes the cell cycle status and the level of apoptosis were detected by flow cytometry. Results:After STAT3 was silent,the lung adenocarcinoma A549 cells in the G0/G1 phase increased (P0.05),while in the S,G2/M phase decreased (P0.05); and apoptosis increased;in the first 48h ,the growth was significant (P0.05),after 48h ,the growth stabilized (P0.05),but still maintain a high level for a long time. Conclusion:STAT3siRNA can block the cell cycle of A549 cells and induce the apoptosis.It suggests that STAT3 expression in A549 cells are closely related with the cell cycle and apoptosis.
【Fund】: 四川省科技厅重点资助基金项目(2006J13-92)
【CateGory Index】: R734.2
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
Chinese Journal Full-text Database 5 Hits
1 YU Hong 1, WEN Xin-pei 2, JIA Mei-lin 3, WEN An-zhi 3, WAN Zi-fen 1 (1.Department of Respiratory, People’s Hospital of Guizhou Province, Guiyang 550002, China; 2.Department of Respiratory, The Affiliated Hospital of Guiyang Medical College, Guiyang 550004, China; 3.Department of Pathology, People’s Hospital of Cuizhou Province, Cuiyang 550002, China);Significance of Expression of p27~(kipl),CyclinE and PCNA in Non-small Cell Lung Cancer[J];Journal of Guiyang Medical College;2003-06
2 Wang Hongcheng,et al Department of Respiratory Medicine,the Affiliated Hospital of Luzhou Medical College;THE RESEARCH OF THE EXPRESSION AND RELATIONSHIP OF STAT3、MRP、LRP IN LUNG ADENOCARCINOMA A549 AND CARP-RESISTANT A549(A549/CARP)[J];Journal of Luzhou Medical College;2006-04
3 ZOU Xiao-nong National Center for Cancer Registries/Nathonal office for Cancer Prevention and Control, Beijing 100021, P.R.China;Epidemiology of lung cancer in China[J];Chinese Journal of Cancer Prevention and Treatment;2007-12
4 GAO Xia, DIAO Lu-ming, CHEN Hong-lei, et al(Department of Pathology, Medical College, Wuhan University, Wuhan,430071,China);Expression of hepatocyte growth factor and its receptor in non -small cell lung carcinoma and its significance[J];Journal of Practical Oncology;2005-01
5 LI Guo sheng 1, ZHANG Dao rong 1, LIU Dong 2, WANG En hua 1, QIU Xue shan 1, ZHANG Li hong 1 (1 Department of Pathology,College of Basic Medical Sciences,China Medical University,Shenyang 110001,China; 2. Department of Pathology ,Tumor Hospi;The Expression and Significance of p34~ (cdc2) in Non-Small Cell Lung Cancer[J];Journal of China Medical University;2002-02
Chinese Journal Full-text Database 10 Hits
1 Qian Zhaoxia,Gao Zhonghe,Hu Enbi,et al Department of Respiratory Diseases,Bengbu Third People's Hospital,Bengbu 233000;Research on plasma endothelin-1,nitrousoxide levels,blood gas analysis in patients with chronic obstructive pulmonary disease[J];Anhui Medical Journal;2008-02
2 Wang Xiaoyuan Hao Xuezhi Zhang Xiangru He Jie Department of Medical Oncology,Cancer Hospital and Institute,Chinese Academy of Medical Sciences & Peking Union Medical College,Beijing 100021,China;Clinical analysis of 35 cases of bronchotracheal adenoid cystic carcinoma[J];Oncology Progress;2009-01
3 WU Chun-feng1,2,MA Zhong-sen1,WANG Xiu-li3,YANG Guang-min4,MA Yin-fu4,YANG Jun-ling1,YIN Jin-zhi1,CHEN Peng1(1.Department of Respiratory Diseases,Second Hospital,Jilin University,Changchun 130041,China;2.Department of Respiratory Diseases,Peoples' Hospital of Jilin Province,Changchun 130021,China;3.Department of Hematology,Second Hospital,Jilin University,Changchun 130041,China;4.Central Laboratory,Peoples' Hospital of Jilin Province,Changchun 130021,China);Determination of T lymphocytes subset and cytokine of Th1/Th2 lymphocytes in peripheral blood mononuclear cells from patients with idiopathic pulmonary fibrosis[J];Journal of Jilin University(Medicine Edition);2008-02
4 Luo Yan Emergency department,Chengdu University of Traditional Chinese Medicine Affiliated Hospital,Chengdu,Sichuan?? 610072;Clinical Observation on Treatment of Acute Attack of Pulmonary Heart Disease Based on Chinese and Western Medicine Integrated Approach[J];Journal of Chengdu University of Traditional Chinese Medicine;2009-02
5 NIU Rong,YANG Yong-zhu,ZHAO Jing,et al.(Department of Cardiothoracic Surgery,Tumor Hospital of Gansu Province,Lanzhou 730050,China);Clinical therapeutic effect of the low tidal volume mechanical ventilation with PEEP matching anisodamine on ARDS patients at high altitude[J];Journal of Traumatic Surgery;2008-05
6 RUAN Yan 1,2 ,HUA Li 1,3 ,HAN Yi-Ping 1 ,XU Hao 1 ,LIN Jian-Dong 2 (1.Department of Respiratory Diseases,Changhai Hospi-tal,Second Military Medical University,Shanghai200433,China;2.Department of Respiratory,Fuzhou Pneumology Hospi-tal,Fuzhou350008;3.The First Clinical College,Medical College,Xiamen University,Department of Emergency,Xiamen Zhongshan Hospital,Xiamen361004) [;Clinical analysis of endobronchial hamartoma:a report of 3 cases[J];Academic Journal of Second Military Medical University;2004-06
7 Zhao Wen - xian, Zhang Xia - guang, Yang Jing - guo, et al. (Beijing Puren Hospital, Beijing 100062, China);Clinical Analysis of Noninvasive Positive Pressure Ventilation on Treatment of Hypoxemia after Operation[J];Chinese Journal of Medicinal Guide;2004-06
8 Zhou Xiao-yan Wang Lu-e Lu Li-yan (Cangzhou Hospital of Combined Traditional and Western Medicine,Cangzhou 061001,China);The Analysis of the Factor of Renal Failure during Medical Treatment to Eldly Acute Heart Failure[J];Chinese Journal of Medicinal Guide;2008-05
9 WANG Hong-jun,LI Hong-bing,WANG Ping-fei,ZHANG Xue-man(Department of Respiratory Diseases,Dazhou Central Hospital,Dazhou 635000,China);Effect of non-invasive positive pressure ventilation in treatment of COPD at acute exacerbation phase combined with typeⅡrespiratory failure in 53 patients[J];Acta Academiae Medicinae Militaris Tertiae;2007-16
10 LIU Zuo-Liang,YANG Ming-Shi,XIAO Xue-Fei ICU,Xiangya Third Hospital,Central South University,Changsha 410078,China;Non-invasive bi-level positive pressure ventilation combined with Allylnoroxymorphone in treatment of COPD combined with pulmonary encephalopathy[J];Journal of the Fourth Military Medical University;2008-17
China Proceedings of conference Full-text Database 5 Hits
1 YANG Hong-zhong HU Cheng-ping YANG Hua-ping QU Su-jie (Department of respiratory disease,Xiang-ya Hospital,Central Southern University,Hunan,Changsha 410008);The role of medical thoracoscopy in the diagnosis of difficult and complicate pleural effusion[A];[C];2007
2 LI Min HU Cheng-ping YANG Hong-zhong YANG Hua-ping QU Su-jie (Department of Respiratory Diseases,Xiang Ya Hospital,Center South University,Changsha,Hunan 410008,P.R.Cbina);Characteristics and changes of lung cancer diagnosed by bronchoscopy in 729 female patients[A];[C];2007
3 Liu Jiahong,,Sun Rongli,Wang Yingnian ,et al. Qingdao Central Hospital 266042;Diagnostic values and clinical significance of detecting soluble FasL of pleural effusions in differentiating tuberculous and malignant pleural effusions[A];[C];2005
4 ;Study of Diagnostic Value of Detection of AM and Combined Detection of AM, C YFRA211, NSE and CEA in Differentiation Pulmonary Tumor from Pulmonary Tuberculosis[A];[C];2005
5 GU Li-gang ZHOU Yun JING Shan NIU Xu-yan WANG Fu ZHANG Chun-jing (Beijing University of Chinese Medicine,Beijing 100029,China);Mechanism of Injury of Lungs in Influenza Virus FM1 Infected Mice and the Intervention of Tanreqing Injection[A];[C];2008
【Secondary Citations】
Chinese Journal Full-text Database 10 Hits
1 WANG Hong, Han Yi-Ping(Department of Respiratory, Changhai Hospital, Second Military Medical University, Shanghai 200433,China);Expression of Stat 3 protein in lung carcinoma and its clinical significance[J];Academic Journal of Second Military Medical University;2001-09
2 GAO Guofu *, YAO Shuxiang, SUN Xiudi, CHANG Runsheng, JIANG Yong, LUO Xuechang, JIN Ping, QIAO Youlin. * Cancer Institute, Chinese Academy of Medical Sciences, Beijing 100021, P.R.China;Establishment of cohort to study lung cancer in Yunnan tin miners[J];Chinese Journal of Lung Cancer;2002-02
3 GAN De-kun, HAN Jing-xiu, ZHENG Su-hua, et al. Institute for Environmental Health and Related Product Safety, Chinese Center for Disease Control and Prevention, Beijing 100021, China;Adverse Effect of Passive Smoking on Women Health[J];Journal of Environment and Health;2006-02
4 WANG Feng Yang, CHANG Zhi Jie ** (Department of Biological Science and Biotechnology, Tsinghua University, Beijing 100084, China);Transcription Factor Stat3 as an Oncogene[J];Progress In Biochemistry and Biophysics;2002-03
5 Xiang Yongbing,Gao Yutang,Cancer Institute of Shanghai Jiaotong University,Shanghai Cancer Institute(200032),Shanghai;Polychotomous Logistic Regression Analysis for Lung Cancer among Nonsmoking Women in Shanghai,P.R.China.[J];Chinese Journal of Health Statistics;2005-02
6 LI Guo sheng 1, ZHANG Dao rong 1, LIU Dong 2, WANG En hua 1, QIU Xue shan 1, ZHANG Li hong 1 (1 Department of Pathology,College of Basic Medical Sciences,China Medical University,Shenyang 110001,China; 2. Department of Pathology ,Tumor Hospi;The Expression and Significance of p34~ (cdc2) in Non-Small Cell Lung Cancer[J];Journal of China Medical University;2002-02
7 CHEN Wan-qing, ZHANG Si-wei, LI Lian-di, et al. (National Center for Cancer Registries, Beijing 100021, China);An Analysis of Lung Cancer Incidence and Mortality from 30 Cancer Registries in China,1998~2002[J];Bulletin of Chinese Cancer;2006-09
8 ZHANG Wei-sen, JIANG Chao-qiang, Lain T. Hing, Ho S. Yin , CHEN Qing, LIU Wei-wei, HE Jian-min, CAO Min. *Guangzhou Occupational Diseases Prevention and Treatment Center, Guangzhou 510620, China;A prospective cohort study on the comparison of risk of occupational dust exposure and smoking to death[J];Chinese Journal of Epidemiology;2004-09
9 WANG Jun, GAO Yu-tang, WANG Xue-li, LIU En-ju, ZHANG Yu-lan, YUAN Jian-min. Shanghai Cancer Institute, Shanghai 200032, China;Cigarette smoking and cancer mortality:a prospective cohort study in urban males in Shanghai[J];Chinese Journal of Epidemiology;2004-10
10 YANG Gong huan,MA Jie min,LIU Na,ZHOU Ling ni. Institute of Basic Medical Sciences,Peking Union Medical College,Chinese Academy of Medical Sciences,Beijing 100005, China;Smoking and passive smoking in Chinese,2002[J];Chinese Journal of Epidemiology;2005-02
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved