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《Journal of Luzhou Medical College》 2011-03
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STUDY ON CLEMATIS SAPONIN IN HIBITING HL-60 CELL GROWTH

Chen Yuru,et al Department of Hematology,the Affiliated Hospital of Luzhou Medical College  
Objective: To observe the inhibition induced by Chinese medicine clematis saponin against human myeloid leukemia cell line HL-60 and investigate the potential mechanism,Methods: Acute leukemic cells were treated by different concentration of clematis saponin for clifferent period of time.The morphology and growth activity were observed.Results:HL-60 cells were inhibited by clematis saponin in a time and concentration dependent manner.By means of morphology examination,cell volume shrinked and nucleus was highly crimpled and aggregated,and even broke to form apoptotic body.Conclusion: This experiment proves that clematis saponin can inhibit the growth of acute leukemic cell,inhibition effect of high concentration clematis sapanin has no significant difference with that of arsenic trioxide.
【CateGory Index】: R285.5
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