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《Geriatrics & Health Care》 2007-05
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Clinical study of oxiracetam for treatment of Alzheimer's disease

YAO Ge,CHENG Jie,WANG Xiao-rong,LIU Zheng-guo Department of Neurology,Xinhua Hospital,Shanghai Jiaotong University School of Medicine,Shanghai 200092,China  
Objective To compare the therapeutic effects and safety of oxiracetam and piracetam in the treatment of mild or medium Alzheimer’s disease. Methods A total of 70 patients with mild or medium Alzheimer’s disease were randomized into oxiracetam group (n=35) and piracetam group (n=35). MMSE and Blessed-Roth scales were used to evaluate the therapeutic effects. Results Except for daily life ability,all other indexes improved after treatment in the patients of both groups,compared with the pre-treatment condition. The differences were statistically significant (P0.01 or P0.05). Compared with piracetam group,the difference in MMSE and Blessed-Roth values was more significant in oxiracetam group (P0.05). The overall curative rate of oxiracetam group was higher than that of piracetam group (63% vs 34% ,P0.01). Conclusions Both oxiracetam and piracetam are effective in the treatment of mild and medium forms of Alzheimer’s disease,and the former is even better than the latter.
【CateGory Index】: R749.16
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