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《Geriatrics & Health Care》 2008-01
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Cardiac impairment in early chronic kidney disease:an experimental study in rats

DU Guo-wei,BAO Xiao-rong Department of Nephrology,Jinshan Hospital,Fudan University,Shanghai 200540,China  
Objective To examine cardiac impairment in early chronic kidney disease(CKD)in a rat model.Methods The early CKD animal model was established by subtotal nephrectomy(70%±2.0%)and shortening the feeding time of the rats(10 weeks).Heart impairment was examined with respect to the heart/body weight ratio,hypertrophy of cardiomyocytes and interstitial fibrosis.Collagen Ⅰ and Ⅲ in myocardial tissue were measured by immunohistochemistry.Results(1)The mean percentage of removed kidney was 70.14±2.00%.In the experimental group,the main pathological change of the kidney was glomerular mesangial proliferation.Focal segmental glomerular sclerosis was rare.Blood urea nitrogen(BUN),the urinary albumin/creatinine ratio and the degree of glomerular mesangial proliferation were higher in the experimental group than those in the control group(P0.01),but there was no significant difference in serum creatinine between the two groups;(2)Compared with the control group,the heart /body weight ratio was higher(P0.01)and pathological changes including hypertrophy of cardiomyocytes and interstitial fibrosis were more severe in the experimental group.Immunohistochemistry results showed that collagenⅠand collagen Ⅲ in the myocardial tissue increased significantly in the experimental group.Conclusions Cardiac impairment was found in the early CKD animal model,mainly including increased heart weight,hypertrophy of cardiomyocytes,interstitial fibrosis,and increased levels of collagenⅠand collagen Ⅲ.
【CateGory Index】: R692;R541
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