Full-Text Search:
Home|Journal Papers|About CNKI|User Service|FAQ|Contact Us|中文
《Practical Pharmacy and Clinical Remedies》 2012-02
Add to Favorite Get Latest Update

Effect of different concentrations of etomidate on the tone of isolated rabbit pulmonary and aortic artery rings before and after LPS incubation

LI Bin-lin,ZHANG Jin,LI Na,TONG Dong-yi(Department of Anesthesiology,Shengjing Hospital of China Medical University,Shenyang 110004,China)  
Objective To observe the effects of etomidate on isolated rabbit pulmonary and aortic artery rings before and after LPS incubation,and provide evidence for narcotic choice of clinic septic shock.Methods The rings of pulmonary and aortic arteries were prepared and randomly divided into 4 groups:normal pulmonary artery rings group,LPS incubated pulmonary artery rings group,normal aortic artery rings group and LPS incubated aortic artery rings group.The effects of etomidate of 1.0 μmol/L,2.0 μmol/L,10.0 μmol/L on pulmonary and aortic arteries in two groups were observed when phenylephrine(PE)pre-contracting.Results The tone of pulmonary and aortic arteries before and after LPS incubated had no significant difference(P0.05)when 1.0 μmol/L of etomidate was given;the tone of normal pulmonary and aortic arteries and LPS aortic arteries increased significantly(P0.05)when 2.0 μmol/L of etomidate was given;the tone of LPS pulmonary and aortic artery rings were significantly lower than those of normal pulmonary and aortic artery rings(P0.05)when 10.0 μmol/L of etomidate was given.Conclusion Etomidate in lower concentration has contractive effect on major,the vasodilation of pulmonary artery caused by etomidate is more obvious than that of aortic artery,along with the increase of concentration,it may correlate to the inhibition of vasoconstriction by high concentration of etomidate.
【Fund】: 沈阳市重点课题(F10-205-1-67、071021)
【CateGory Index】: R965
Download(CAJ format) Download(PDF format)
CAJViewer7.0 supports all the CNKI file formats; AdobeReader only supports the PDF format.
【Citations】
Chinese Journal Full-text Database 3 Hits
1 HUANG Xin-Li, LING Yi-Qun, ZHU Tie-Nian, ZHANG Jun-Lan, LING Yi-Ling Department of Pathophysiology, Hebei Medical University, Shijiazhuang 050017, China;Multiple factors contributing to lipopolysaccharide-induced reactivity changes in rabbit pulmonary artery[J];Acta Physiological Sinica;2005-06
2 SUN Kai, ZHANG Jin-song, XU Xin-rong. The First Affiliated Hospital of Nanjing Medical University, Nanjing 210029, China;Antishock role of vasopressin in endotoxin shock in rabbits[J];The Journal of Practical Medicine;2008-04
3 GU Zhen-Yong, LING Yi-Ling, MENG Ai-Hong, CONG Bin, HUANG Shan-Sheng Department of Pathophysiology, Hebei Medical University, Shijiazhuang(050017);Effects of cholecystokinin octapeptide on the response of rabbit pulomonary artery induced by LPS in vitro[J];CHINESE JOURNAL OF PATHOPHYSIOLOGY;1999-06
【Co-citations】
Chinese Journal Full-text Database 10 Hits
1 MA Li-Qin, GU Zhen-Yong, DONG Guo-Kai, LI Na, GAO Feng, LIU Xia, MA Chun-Ling, CONG Bin, LING Yi-Ling Department of Forensic Medicine and Pathophysiology, Hebei Medical University, Shijiazhuang 050017, China;Effect of cholecystokinin octapeptide on LPS-induced SOD mRNA expression and increase of NF-κB activity in rat vascular smooth muscle cells induced by LPS[J];Journal of the Fourth Military Medical University;2006-20
2 MENG Ai-Hong, LING Yi-Ling *, WANG Dian-Hua, GU Zhen-Yong, LI Shu-Jin, ZHU Tie-Nian (Department of Pathophysiology, Hebei Medical University, Shijiazhuang 050017);Role of nitric oxide in cholecystokinin-octapeptide alleviation of tumor necrosis factor-alpha induced changes in rabbit pulmonary arterial reactivity[J];Acta Physiological Sinica;2001-06
3 DUAN Guo-Chen, LING Yi-Ling *, GU Zhen-Yong, WEI Peng, NIU Zhi-Yun, YANG Shi-FangDepartment of Pathophysiology, Hebei Medical University, Shijiazhuang 050017;Effects of cholecystokinin-octapeptide on the tension of pulmonary artery in rabbits with endotoxic shock[J];Acta Physiological Sinica;2003-02
4 GU Zhen-Yong~1,2, LING Yi-Ling~2, XU Xiao-Hu~1, MENG Ai-Hong~2, LI Shu-Jin~2 1 Shantou University Medical College, Shantou 515031; 2 Department of Pathophysiology, Hebei Medical University, Shijiazhuang 050017;Effect of peroxynitrite on the reactivity of rabbit pulmonary arteries in vitro[J];Acta Physiological Sinica;2003-04
5 HUANG Xin-Li*, ZHOU Xiao-Hong, WEI Peng, ZHANG Xiao-Jing, MENG Xiang-Yan, XIAN Xiao-Hui Department of Pathophysiology, Hebei Medical University, Shijiazhuang 050017, China;Role of endogenous hydrogen sulfide in pulmonary hypertension induced by lipopolysaccharide[J];Acta Physiologica Sinica;2008-02
6 LI Shu-jin 1, LING Yi-ling 1, WANG Dian-hua 1, GU Zhen-yong 1, MENG Ai-hong 1, ZHU Tie-nian 1, HE Ying 2 (? 1?Department of Pathophysiology, Hebei Medical University, Shijiazhuang 050017, China; ? 2?Department of Endocrinology, Beijing Army G;Effects of cholecystokinin octapeptide on changes in rabbit thoracic aortic reactivities induced by lipopolysaccharides in vitro[J];Chinese Journal of Pathophysiology;2001-11
7 ZHAO Xiao-yun, LING Yi-ling, MENG Ai-hong, HUANG Xin-li, ZHANG Jun-lan (Department of Pathophysiology, Hebei Medical University, Shijiazhuang 050017, China);Effects of endogenous carbon monoxide/nitric oxide on cholecystokinin octapeptide reversed vascular hyporeactivity in endotoxemic rats[J];Chinese Journal of Pathophysiology;2002-02
8 LI Shu-jin, LING Yi-ling, CONG Bin (Department of Pathophysiology, Hebei Medical University, Shijiazhuang 050017, China );Cholecystokinin and lung[J];Chinese Journal of Pathophysiology;2002-03
9 CONG Bin,LING Yi-ling,GU Zhen-yong,WANG Jun-xia, YAO Yu-xia (Department of Pathophysiology, Hebei Medical University ,Shijiazhuang 050017, China);Inhibitory effect of cholecystokinin octapeptide on NF-κB activity induced by lipopolysaccharide in rat lungs[J];Chinese Journal of Pathophysiology;2002-06
10 HUANG Xin-li 1,LING Yi-ling 1,LU Ping 1,LIU Yan 2,WANG Jian-qin 1,AI Jie 1 ( 1Department of Pathophysiology,? 2?Department of Histology and Embryology,Hebei Medical University,Shijiazhuang 050017,China);Change of c-fos in CCK-8 against the pulmonary artery smooth muscle cell injury induced by LPS[J];Chinese Journal of Pathophysiology;2003-11
【Secondary Citations】
Chinese Journal Full-text Database 4 Hits
1 XU Yan-shuo,DI Cheng-shun,LIANG Yan-bing,TANG Hao,MA Zhong-fu(Emergency Medicine,Shilong People's Hospital of Dongguan City,Dongguan 523721,China);Study of the Myocardial Apoptosis and Its Correlation with the Expression of the Bcl-2 Protein in Septic Rats[J];Journal of Tropical Medicine;2007-07
2 LING YI-LING AND SHAN-SHENG(Institute of Basic Medicine,Hebei Medical University,Shijiazhuang 050017)WANG LE-FENG,ZHANG JUN-LAN WAN MEI AND HAO RONG-LI;CHOLECYSTOKININ-OCTAPEPTIDE (CCK-8)REVERSES EXPERIMENTAL ENDOTOXIN SHOCK[J];ACTA PHYSIOLOGICA SINICA;1996-04
3 Wang Le一Feng; Ling Yi一Ling;Huang Shan一Sheng; Zhang Jun一Lan;Wang Mei;Hao Rong一Li(Department of Pathophysioloyg,Hebei Medical Universrty,Shijiazhuang(050017);Clearance of cholecystokinin(CCK)by lung during normal and endotoxic shock[J];CHINESE JOURNAL OF PATHOPHYSIOLOGY;1996-06
4 Ling Yi-Ling,Huang Shan-Sheng,Zhang Jun-Lan,Wan Mei,Hao Rong-LiDepartment of Pathophysiology,Hebei Medical University,Shijiazhuang(050017);Effect of cholecystokinin on SOD、MDA contents and phagocyte chemiluminescence of reversing endotoxin shock rat[J];CHINESE JOURNAL OF PATHOPHYSIOLOGY;1997-05
©2006 Tsinghua Tongfang Knowledge Network Technology Co., Ltd.(Beijing)(TTKN) All rights reserved