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《Practical Pharmacy and Clinical Remedies》 2012-02
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Effect of different concentrations of etomidate on the tone of isolated rabbit pulmonary and aortic artery rings before and after LPS incubation

LI Bin-lin,ZHANG Jin,LI Na,TONG Dong-yi(Department of Anesthesiology,Shengjing Hospital of China Medical University,Shenyang 110004,China)  
Objective To observe the effects of etomidate on isolated rabbit pulmonary and aortic artery rings before and after LPS incubation,and provide evidence for narcotic choice of clinic septic shock.Methods The rings of pulmonary and aortic arteries were prepared and randomly divided into 4 groups:normal pulmonary artery rings group,LPS incubated pulmonary artery rings group,normal aortic artery rings group and LPS incubated aortic artery rings group.The effects of etomidate of 1.0 μmol/L,2.0 μmol/L,10.0 μmol/L on pulmonary and aortic arteries in two groups were observed when phenylephrine(PE)pre-contracting.Results The tone of pulmonary and aortic arteries before and after LPS incubated had no significant difference(P0.05)when 1.0 μmol/L of etomidate was given;the tone of normal pulmonary and aortic arteries and LPS aortic arteries increased significantly(P0.05)when 2.0 μmol/L of etomidate was given;the tone of LPS pulmonary and aortic artery rings were significantly lower than those of normal pulmonary and aortic artery rings(P0.05)when 10.0 μmol/L of etomidate was given.Conclusion Etomidate in lower concentration has contractive effect on major,the vasodilation of pulmonary artery caused by etomidate is more obvious than that of aortic artery,along with the increase of concentration,it may correlate to the inhibition of vasoconstriction by high concentration of etomidate.
【Fund】: 沈阳市重点课题(F10-205-1-67、071021)
【CateGory Index】: R965
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