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《Practical Pharmacy and Clinical Remedies》 2015-07
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Effects of high dose ambroxol hydrochloride in the treatment of pulmonary damage in acute paraquat poisoning

WANG Yu;LIU Zhen-ning;ZHAO Min;Department of Emergency,Shengjing Hospital of China Medical University;  
Objective To observe the effect of high dose ambroxol hydrochloride in the treatment of pulmonary damage in acute paraquat poisoning. Methods Forty patients of acute paraquat poisoning w ith pulmonary damage w ere randomly divided into 2 groups: control group( n = 20) and treatment group( n = 20). Control group received conventional therapy,and the treatment group w as added w ith intravenous infusion of ambroxol hydrochloride 20 mg /( kg·d) q12 h for 5 d. The artery blood gas,HRCT film changes,the number of cases with multiple organ dysfunction syndrome( MODS),mortality,and survival time of the death cases w ere observed. Serum MDA,SOD and TNF-α,IL-6 levels w ere measured in 2 groups before treatment and at 5 d after treatment. Results After treatment,the oxygen partial pressure,oxygenation index,and HRCT film changes w ere all improved in the 2 groups( P 0. 01 or P 0. 05),there w as significant difference betw een the tw o groups( P 0. 05). The number of MODS cases in treatment group w ere low er than those in control group( P 0. 05),but no significant difference w as found in mortality betw een the tw o group( P 0. 05). After treatment,plasma level of MDA all decreased in the 2 groups,there w as significant difference betw een the tw o groups( P 0. 05); plasma level of SOD all rose in the 2 groups,there w as significant difference betw een the tw o groups( P 0. 05). After treatment,plasma level of TNF-α,IL-6 all decreased in the 2groups,there w as significant difference betw een the tw o groups( P 0. 05). Conclusion High dose ambroxol can be adopted to improve the ability of anti-oxidantion of the organism,inhibit lipid peroxidation and the levels of proinflammatory factor,lessen pulmonary damage,thus it has a certain therapeutic effect for treatment of acute paraquat poisoning.
【Fund】: 国家临床重点专科建设项目卫办医政函2012[649号]
【CateGory Index】: R595.4;R563
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