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《Journal of Brain and Nervous Diseases》 2001-02
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Detection of serum amyloid protein and polypeptid growth factor in Alzheimer disease and vasular dementia and their correlation study

LUO Nan-Ping, YANG Dao-Li, CHEN-Qing, PENG Li-Yi, SUN Xiao-Ming, LIU Gui-Xiang. Department of Immunology, Grneral Hospital of Jinan Military Region (250031)  
Objective: To study the changes of amyloid protein (β-AP) and polypeptide growth factor levels and their correlation, analyse their role in the pathogenesis of Alzheimer disease (AD) and vasular dementia (VI)). Methods: By radio immuneassay, We detected serumβ-AP, transforming growth factor-a(TGF-α) and insulin-like growth factor (IGFI ) levels in 8 AD, 15 VD and 63 ischemic cerebrovascular disease (ICVD) patients, and compared twith that of 50 cases control group. Results: In AD and VD group, serumβ3-AP, β-AP are signipicantly higher than that in ICVD and control group; ICVD group serumβ3-AP, TGF-α and IGF- Ⅱ contents are obviously higher than that in normal control, the highest increase occurred in sequel of cerebral infarction (SCI) and vertebrobasislar ischemia (SCI) group. There are positive correlation among AP, TFG-a and IGF- Ⅱ in AD an VD group. Conclusion: ①β3-AP is a risk factor in the pathogenesis of AD and VD. ②TGF-α and IGF- Ⅱ play a role in the neurotoxin effect that lead to dementia.③Abnormal metabolism ofβ3- AP, TGF-α and IGF- Ⅱ in ICVD patients are important that induce VD.
【CateGory Index】: R749.16
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