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《Pediatric Emergency Medicine》 2005-06
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Change and significance of surfactant protein A in BALF of newborns with pulmonary hemorrhage

CAI Xu-xu,GAO-Fei,GAO Hong,et al.NO.2 Clinical Hospital,China Medical University,Shenyang 110004,China.  
Objective To study the change of surfactant protein A(SP-A)in bronchoalveolar lavage fluid(BALF)and the relationship with prognosis in newborns with pulmonary hemorrhage.Methods SP-A was measured by Western-dot blot analysis in group control(n=15),group survival with pulmonary hemorrhage within an acute phage(survival,n=14),group survival with pulmonary hemorrhage within a recover phage(recovery,n=14)and group death(death,n=6).Results The content of SP-A in BALF in newborns with pulmonary hemorrhage was significantly lower than that in group control(P0.01).The level of SP-A in BALF in group death was found significantly lower than that in group survival(P0.05).The level of SP-A in group recovery elevated to approach that in group control(P0.05).Conclusion The content of SP-A in BALF may be considered as an indicator of the predict and the prognosis of pulmonary hemorrhage in newborns.
【CateGory Index】: R722.1
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