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《Journal of Liaoning University of Traditional Chinese Medicine》 2008-01
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Effect of Shengjiang Powder on Expression of ICAM-1 of Lung Tissue Cells in Acute Lung Injury Rats

CHANG Jia-song,WEI Kai-feng,XU De-guo(Nanjing University of Chinese Medicine,Nanjing 210029,Jiangsu,China)  
Objective:To investigate the therapeutic mechanism of Shengjiang Powder on acute lung injury.Methods:Totally 24 healthy SD male rats of were divided into 3 groups by random: control group,model group,therapeutic group.At the 6th day after administration,reproduce acute lung injury rat models by injecting LPS into sublingual vein.Detected the expression of ICAM-1 in the cytoplasm of terminal bronchiole epithelial cells by assessing lung histological sections by immmunohistochemistry.Capture the images and measured the average gray values of nucleus of lung micrangium endothelial cells.Results: Compared with model groupS,hengjiang Powder could depress the expression of ICAM-1 in the cytoplasm of terminal bronchiole epithelial cells;statistical difference existed between the treating groups and model group.Conclusion:Shengjiang Powder can preventing and treating acute lung injury by inhibiting inflammatory damage on lung tissues through depressing the expression of ICAM-1 in the cytoplasm of terminal bronchiole epithelial cells.
【CateGory Index】: R285.5
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