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《Journal of Liaoning University of Traditional Chinese Medicine》 2010-03
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Clinical Study of Using Yangxinshi Pill Treating Patients with Qi Deficiency Blood Stagnation Syndrome and Chronic Heart Failure Caused by Coronary Heart Disease

ZHANG Wei, LU Wei-xing (Department of Cardiology, Dongzhimen Hospital of Beijing University of Chinese Medicine, Beijing 100700, China)  
Objective: To disclose the clinical influnce of Yangxinshi pill on patients with Qi deficiency blood stagnation syndrome and chronic heart failure caused by coronary heart disease. Methodes: We studied this thesis adopting stratified random, multi center, positive medicine parallel contrast clinical research method, adopting 77 patients who visited cardio and vessel section of DongZhiMen hospital which affiliated Beijing TCM university, GuangAnMen hospital which affiliated China TCM Academy and Beijing TCM hospital which affiliated Capital Medicine university, contrasting with Lotinsin and Betaloc as the positive medicine. We observed such indexes as cardiac function, symptomes of TCM, 6-minute- walk trail, echocardiogram, the stopping and decreasing rate of Digoxin, the stopping and decreasing rate of Hydrodiuril, adverse reactions and so on. Result: There is no remarkable difference in following aspects as general curative effect of TCM Syndromes, cardiac function curative effect (NYHA grading standards), 6-minute-walk trail curative effect, the stopping and decreasing rate of Digoxin, the stopping and decreasing rate of Hydrodiuril after statistics analysis between the two group(P0.05). The curative effect of the test group is better than that of the contrast group in the following aspects: asthenia, sweating, darkish complexion and picture of tongue (P0.05). The contrast group is better than the test group in decreasing heart rate and blood pressure, however the test group can decrease systolic pressure too. There is no statistical difference by contrast their echocardiogram index (LVEF, FS, E peak, A peak, E/A) before and after therapy (P0.05), although LVEF, FS, E peak and E/A of the two groups manifest increasing trend, A peak of the two groups manifest decreasing trend. In adverse reaction aspect, 1 patient of the test group appears sickness and abdominal distention. 1 patient of the test group appears slight dry mouth, these can't affect their continuing taking medicine. We can't find severe adverse reactions. Conclusion: Yangxinshi pill can improve the heart function, can improve symptom of the patient with chronic heart failure caused by coronary heart disease. Few adverse reaction, it is an efficient medicine to treat the patient with CHF caused by CHD, TCM syndrome belonging to Qi deficiency blood stagnation.
【CateGory Index】: R259
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