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Schisandra Extracts on Blood Glucose of Diabetic Mice

FENG Shi-hua1,WANG Qing-zhou2,LI Fen-ge2,SHAO Liang2,LIU Jian-ying3(1.Qinghe County Lianzhuang Town Health Center,Qinghe 054800,Hebei,China;2.Xingtai City Fifth Hospital,Xingtai 054000,Hebei,China;3.Diabetes Research Institute in Xingtai City,Xingtai 054000,Hebei,China)  
Objectives:Of Schisandra extract obtained by the different solvents on the blood glucose of diabetic mice and diabetic symptoms.Method:The Wuwei Zi were treated with water,ethanol,ethyl acetate,and petroleum ether extraction,by 4 different extracts.Abdominal injection of mice with alloxan 200mg/kg,of diabetes model.Were given to alloxan diabetic mice fed Wuwei Zi extracts 0.5g/kg.Determination of blood glucose and serum insulin levels,body weight of mice,food intake and water intake and general condition,light microscopy of pancreatic tissue morphology and disease in mice immunohistochemical β-cell situation.Results:Schisandra alcohol extract and water extract could increase serum insulin levels of diabetic mice,reducing blood sugar,diabetic symptoms;two groups of insulin secretion in mice significantly improved cell morphology,increased number of secretory cells,immunohistochemistry showed positive β-cells expression was significantly increased number;alcohol extract was better than the water extract,but not statistically significant.Acetate extract and ether extract lower blood sugar in diabetic mice with little effect.Conclusion:Schisandra of different solvent extracts from alcohol extract and water extract significantly improved the role of blood glucose in diabetic mice,Schisandra may be by reducing β-cell damage and repair,improve insulin to lower blood sugar levels.
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