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《Journal of Liaoning University of Traditional Chinese Medicine》 2013-06
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Chemical Constituents from Notopterygium Root

TIAN Yujie 1,2,LI Jinnan 2,FENG Jinlei 2,WANG Quan 2,3,ZHANG Cuiying 1,ZHOU Honggang 2,4,CHEN Weiqiang 2,YANG Cheng 2,4,5(1.School of Biological Engineering,Tianjin University of Science and Technology,Tanjin 300457,China;2.High-throughout Molecular Drug Discovery Center,Tianjin International Joint Academy of Biotechnology & Medicine,Tianjin 300457,China;3.College of Life Sciences of Nankai University,Tianjin 300071,China;4.College of Pharmacy Nankai University,Tianjin 300071,China;5.State Key Laboratory of Medicinal Chemical Biology,Tianjin 300071,China)  
Objective :To investigate the chemical constituents from Notopterygium root.Methods : The compounds were isolated by chromatography and recrystallisation,and their structures were identified on the basis of physicochemical characteristics and spectroscopic analyses.Results :Eleven compounds were isolated and identified as(±)apterin(1),isopimpinellin(2),ferulic acid(3),phellopterin(4),pimpinellin(5),sphondin(6),bergapten(7),isobergapten(8),fumaric acid(9),isopsoralen(10)and(±)vaginidiol(11).Conclusion :Most of the chemical compositions of Notopterygium root phenylpropanoids,and(±)apterin(1),fumaric acid(9),isopsoralen(10)and(±)vaginidiol(11) are obtained from the plant of Notopterygium root for the first time.
【Fund】: “重大新药创制”国家科技重大专项项目(2009ZX09301-008);; 科技型中小企业创新基金项目(天津11ZXCXSY 03500 国家11C26211 203971)
【CateGory Index】: R284
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