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《Journal of Lanzhou University(Medical Sciences)》 2006-04
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Study on the utilization of active carbon to remove pyrogens from tetanus antitoxin

ZHANG Jin ZHANG Yu-jia JIN Yu JIANG Lie JIN Xue-min (Lanzhou Institute of Biological Products,Lanzhou,730046,China)  
Objective To study the utilization of active carbon to remove pyrogens from tetanus antitoxin.Methods Four batches of tetanus antitoxin with higher pyrogens over the national standard were tested after being adsorbed by active carbon under certain pH value and tempera- ture.Results Active carbon was very effective to remove pyrogens,the average temperature was decreased by 0.66℃and the content of protein in the products was averagely decreased by 9.08%, the specific activity was increased averagely by 8.16%,and the rate of recovery of product was over 98%.Conclusion This method was quick,simple,effective and repetitive in the removal of pyrogens from tetanus antitoxin.
【CateGory Index】: R392.7
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