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Observation of Effects of L-arginine and N-acetylcystiene on Pulmonary Damage Induced bv Oleic Acid Infusion in Mice

Zhu Yunkui et al.(Jing Cheng Hospital of Lanzhou,China)  
his paper deals with the effects of L-arginine(ARG)and N-acetylcysteine(NAC)on acute lung in-jury hy infusion of oleic acid. 115 mice were divided into five groups:control grotip(CG,n=20),injurygroup(IG,n=35),NAC group(NG,n=20),ARG group (AG,n=20) and Tnixed group(MG n=20),Thelungs were injuried by oleic acid (0.15ul/g)infusion in tail vein in IG and treated groups, NAC or/and ARGwas infused in treated groups at once after olieic acid infusion.The result showed that death rate was 14%in IG vs 0 in NG,AG and MG respectively.The lung index was markedly decreased(0.012±0.003,0.010±0.002 and 0.089±0.003 vs 0.016±0.001 for NG,AG and MG vs.IC,respectively,P0.05,P0.01)in treated groups;MDA,TXB2 and 6-keto-PGF1α of lung tissue in treated groups were much lower thanthat in IG.The pothology of Iung showed that the lung injury in NG and AG was much lighter than that in IG.We conclude that ARG and NAC may protect and treat acute lung injury induced by oleic acid infusion.
【CateGory Index】: R563.05
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